KMN-80

Product Name: KMN-80
CAS No.: 1628759-75-0
Chemical Name: KMN-80
Synonyms: KMN-80;KMN80,KMN 80;CBIUADIJQPJQEZ-VIDOSBHOSA-N;7-((R)-2-((3S,4S,E)-3-hydroxy-4-methylnon-1-en-6-yn-1-yl)-5-oxopyrrolidin-1-yl)heptanoicacid;1-Pyrrolidineheptanoic acid, 2-[(1E,3S,4S)-3-hydroxy-4-methyl-1-nonen-6-yn-1-yl]-5-oxo-, (2R)-
CBNumber: CB23152663
Molecular Formula: C21H33NO4
Formula Weight: 363.49
MOL File: 1628759-75-0.mol

More

Less

KMN-80 Property

Boiling point:: 572.1±50.0 °C(Predicted)
Density: 1.121±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
pka: 4.77±0.10(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 15435
Product name: KMN-80
Purity: ≥98%
Packaging: 500μg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 15435
Product name: KMN-80
Purity: ≥98%
Packaging: 100μg
Price: $45
Updated: 2021/12/16

Cayman Chemical

Product number: 15435
Product name: KMN-80
Purity: ≥98%
Packaging: 1mg
Price: $169
Updated: 2024/03/01

ChemScene

Product number: CS-0068364
Product name: KMN-80
Packaging: 1mg
Price: $280
Updated: 2021/12/16

AK Scientific

Product number: 3896DW
Product name: 7-[(2R)-2-[(E,3S,4S)-3-Hydroxy-4-methylnon-1-en-6-ynyl]-5-oxopyrrolidin-1-yl]heptanoicacid
Packaging: 1mg
Price: $282
Updated: 2021/12/16

More

Less

KMN-80 Chemical Properties,Usage,Production

Description

The prostaglandin E receptor 4 (EP₄) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E₂ (PGE₂; ). Binding of PGE₂ to the EP₄ receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis.^1,2,3,4 KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE₁ that acts as a selective and potent agonist of EP₄ with an IC₅₀ value of 3 nM (IC₅₀ = 1.4 μM for EP₃ and > 10 μM for all other prostanoid receptors).⁵ In functional assays it has been shown to stimulate secreted alkaline phosphatase gene reporter activity in EP₄-transfected HEK293 cells with an EC₅₀ value of 0.19 nM, demonstrating >5,000 and 50,000-fold selectivity against EP₂ and TP, respectively.⁵ KMN-80 can induce the differentiation of bone marrow stem cells from both young and aged rats into osteoblasts in vitro (EC₅₀s = 20 and 153 nM, respectively) and exhibits favorable tolerability up to at least 10 μM, whereas the EP₄ agonist L-902,688 is highly cytotoxic at similar concentrations in these cells.⁶ KMN-80 has been used to repair calvarial defects in an in vivo rat craniomaxillofacial reconstruction model (rate of reduction in defect size equivalent to BMP-2 treated rats) and to promote bone formation in a rat incisor tooth socket model.⁶

References

1. Li, M., Thompson, D.D., and Paralkar, V.M. Prostaglandin E₂ receptors in bone formation Int. Orthop. 31(6),767-772(2007).
2. Hawcroft, G., Ko, C.W.S., and Hull, M.A. Prostaglandin E₂-EP₄ receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells Oncogene 26(21),3006-3019(2007).
3. Babaev, V.R., Chew, J.D., Ding, L., et al. Macrophage EP₄ deficiency increases apoptosis and suppresses early atherosclerosis Cell Metab. 8(6),492-501(2008).
4. Konya, V., Marsche, G., Schuligoi, R., et al. E-type prostanoid receptor 4 (EP₄) in disease and therapy Pharmacol. Ther. 138(3),485-502(2013).
5. Barrett, S.D., Ciske, F.L., Endres, G.W., et al. Novel Potent Lactam Acetylene EP₄ Agonists Stimulate Alkaline Phosphatase Production and Differentiation in Bone Marrow Cells ,(2014).
6. O'Malley, J., Uzieblo, A., Germain, B.D., et al. Development of a novel prostaglandin EP₄ agonist which stimulates local bone formation in vivo ,(2014).

KMN-80 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

KMN-80 Suppliers

China 20 United States 2 Global 22

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Hangzhou Synstar pharmaceutical Technology CO.,Ltd

Tel: 0571-85361029
Fax: 0571-85361029
Email: synstar518@163.com
Country: China
ProdList: 1990
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11974
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6743
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6025
Advantage: 58

Shanghai Gantu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 1920192055@qq.com
Country: CHINA
ProdList: 1843
Advantage: 58

Shanghai Benrui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: john.st@163.com
Country: CHINA
ProdList: 1471
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6600
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Haoran Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 470003480@QQ.COM
Country: CHINA
ProdList: 6955
Advantage: 58

Boao Pike

Tel: --
Fax: --
Email: lyn@biopike.com.cn
Country: CHINA
ProdList: 6629
Advantage: 58

Shanghai Yaoyun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 912529879@qq.com
Country: CHINA
ProdList: 6835
Advantage: 58

Shanghai Jijin Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jijinhuaxue@sina.com
Country: CHINA
ProdList: 6606
Advantage: 58

Beijing Bolide Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1985563437@qq.com
Country: CHINA
ProdList: 6158
Advantage: 58

Shanghai Minmin Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1914109725@qq.com
Country: CHINA
ProdList: 6518
Advantage: 58

1628759-75-0, KMN-80Related Search:

KMN-80

CBIUADIJQPJQEZ-VIDOSBHOSA-N

1-Pyrrolidineheptanoic acid, 2-[(1E,3S,4S)-3-hydroxy-4-methyl-1-nonen-6-yn-1-yl]-5-oxo-, (2R)-

KMN80,KMN 80

7-((R)-2-((3S,4S,E)-3-hydroxy-4-methylnon-1-en-6-yn-1-yl)-5-oxopyrrolidin-1-yl)heptanoicacid

1628759-75-0