ChemicalBook > CAS DataBase List > M2698

M2698

Product Name
M2698
CAS No.
1379545-95-5
Chemical Name
M2698
Synonyms
M2698;M2698, 10 mM in DMSO;M2698 (MSC-2363318A);M2698; M-2698; M 2698; MSC-2363318A; MSC 2363318A; MSC2363318A;(S)-4-(2-(azetidin-1-yl)-1-(4-chloro-3-(trifluoromethyl)phenyl)ethylamino)quinazoline-8-carboxamide;4-{[(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino}quinazoline-8-carboxamide;8-Quinazolinecarboxamide, 4-[[(1S)-2-(1-azetidinyl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino]-;4-[(S)-2-azetidin-1-yl-1-(4-chloro-3-trifluoromethylphenyl)ethylamino]quinazoline-8-carboxylic acid amide
CBNumber
CB23152911
Molecular Formula
C21H19ClF3N5O
Formula Weight
449.86
MOL File
1379545-95-5.mol
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M2698 Property

solubility 
DMSO: soluble
form 
A solid
color 
White to off-white
InChIKey
HXAUJHZZPCBFPN-QGZVFWFLSA-N
SMILES
N1=C2C(C=CC=C2C(N)=O)=C(N[C@@H](C2=CC=C(Cl)C(C(F)(F)F)=C2)CN2CCC2)N=C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0019628
Product name
M2698
Purity
99.74%
Packaging
5mg
Price
$650
Updated
2021/12/16
DC Chemicals
Product number
DC10751
Product name
M2698(MSC-2363318A)
Purity
>98%
Packaging
100mg
Price
$750
Updated
2021/12/16
DC Chemicals
Product number
DC10751
Product name
M2698(MSC-2363318A)
Purity
>98%
Packaging
250mg
Price
$1300
Updated
2021/12/16
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M2698 Chemical Properties,Usage,Production

Uses

M2698 (MSC2363318A) is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity[1].

in vivo

M2698 (10-30 mg/kg/day; PO; 28 days) results in dose-dependent inhibition of tumor growth and results in tumor regression with the highest dose of 30 mg/kg[1].
? M2698 (20 mg/kg/day; PO; 4 days) has a tumor:plasma exposure ratio of 12:1 over 24 hours and leads to increased levels of pAkt in tumor tissue[1].
? The mean total concentration of M2698 after 16-hour infusion in rats is 1750 ng/g and 175 ng/mL in brain and plasma, respectively[1].
? M2698 (po; 1, 5, 10, or 20 mg/kg/day; for 7 days) inhibits the phosphorylation of S6 in a dose-proportional manner over time after a single administration or daily treatments over 7 days[1].

Animal Model:Female nude mice bearing MDA-MB-468 tumors[1]
Dosage:10, 20 and 30 mg/kg
Administration:PO; daily; for 28 days
Result:Resulted in dose-dependent inhibition of tumor growth and resulted in tumor regression with the highest dose of 30 mg/kg.
Animal Model:Female SCID Beige mice with MDA-MB-453 xenografted[1]
Dosage:20 mg/kg (Pharmacokinetic Analysis)
Administration:Daily; for 4 days
Result:Had a tumor:plasma exposure ratio of 12:1 over 24 hours.

IC 50

p70S6K: 1 nM (IC50); Akt1: 1 nM (IC50); Akt3: 1 nM (IC50)

References

[1] Machl A, et al. M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. Am J Cancer Res. 2016 Mar 15;6(4):806-18. PMID:27186432

M2698 Preparation Products And Raw materials

Raw materials

Preparation Products

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M2698 Suppliers

China 52 United States 4 Global 56
SuZhou GoodChemTech Co., Ltd
Tel
18136139868; 18136139868
Email
jinlun@goodchemtech.cn
Country
China
ProdList
284
Advantage
58
Zhengzhou Haode Pharmaceutical Technology Co.,Ltd
Tel
18037386321
Email
3330511471@qq.com
Country
China
ProdList
500
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Shanghai YuanQi Biotechnology Co., Ltd.
Tel
+86-2332782371 +86-18120098618
Email
sales@adobechem.com
Country
China
ProdList
1250
Advantage
50
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4769
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
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View Lastest Price from M2698 manufacturers

Career Henan Chemical Co
Product
M2698 1379545-95-5
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-25

1379545-95-5, M2698Related Search:


  • M2698
  • (S)-4-(2-(azetidin-1-yl)-1-(4-chloro-3-(trifluoromethyl)phenyl)ethylamino)quinazoline-8-carboxamide
  • M2698 (MSC-2363318A)
  • M2698; M-2698; M 2698; MSC-2363318A; MSC 2363318A; MSC2363318A
  • 4-[(S)-2-azetidin-1-yl-1-(4-chloro-3-trifluoromethylphenyl)ethylamino]quinazoline-8-carboxylic acid amide
  • 8-Quinazolinecarboxamide, 4-[[(1S)-2-(1-azetidinyl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino]-
  • 4-{[(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino}quinazoline-8-carboxamide
  • M2698, 10 mM in DMSO
  • 1379545-95-5