ChemicalBook > CAS DataBase List > ER-000444793

ER-000444793

Product Name
ER-000444793
CAS No.
792957-74-5
Chemical Name
ER-000444793
Synonyms
ER-000444793;ER-000444793 (ER000444793);N-(2-Benzylphenyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide;4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-;Mitochondrial Metabolism,Inhibitor,ER-000444793,inhibit,ER000444793,ER 000444793
CBNumber
CB23155149
Molecular Formula
C23H18N2O2
Formula Weight
354.4
MOL File
792957-74-5.mol
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ER-000444793 Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 100 mg/mL (282.17 mM)
form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7582
Product name
ER-000444793
Purity
>98.0%
Packaging
1mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-7582
Product name
ER-000444793
Purity
>98.0%
Packaging
5mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-7582
Product name
ER-000444793
Purity
>98.0%
Packaging
10mg
Price
$660
Updated
2021/12/16
ChemScene
Product number
CS-7582
Product name
ER-000444793
Purity
>98.0%
Packaging
50mg
Price
$2340
Updated
2021/12/16
ChemScene
Product number
CS-7582
Product name
ER-000444793
Purity
>98.0%
Packaging
100mg
Price
$3540
Updated
2021/12/16
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ER-000444793 Chemical Properties,Usage,Production

Biological Activity

ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening. It inhibits mPTP with IC50 of 2.8 μM.

in vitro

ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. It potently and dose-dependently inhibits Ca 2+ -induced mPT. It binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC 50 =23 nM and SfA IC 50 = 5 nM). In contrast, ER-000444793 has no effect up to a concentration of 50 μM, indicating lack of displacement of labelled -CsA from rhCypD protein. Together, these data suggest the mechanism of it in delaying mPT is independent of CypD functional inhibition.

target

IC50: 2.8 μM (mPTP)

ER-000444793 Preparation Products And Raw materials

Raw materials

Preparation Products

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ER-000444793 Suppliers

China 25 United States 5 USA 1 Global 31
Shanghai Boyle Chemical Co., Ltd.
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792957-74-5, ER-000444793Related Search:


  • ER-000444793
  • ER-000444793 (ER000444793)
  • 4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-
  • N-(2-Benzylphenyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide
  • Mitochondrial Metabolism,Inhibitor,ER-000444793,inhibit,ER000444793,ER 000444793
  • 792957-74-5