MI-538

Product Name: MI-538
CAS No.: 1857417-10-7
Chemical Name: MI-538
Synonyms: MI-538;MI538; MI 538;MI-538, 10 mM in DMSO;MI538,inhibit,Epigenetic Reader Domain,Inhibitor,MI-538,MI 538;1-((1H-pyrazol-4-yl)methyl)-6-hydroxy-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile;1H-Indole-2-carbonitrile, 6-hydroxy-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-
CBNumber: CB23158771
Molecular Formula: C27H25F3N8OS
Formula Weight: 566.6
MOL File: 1857417-10-7.mol

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MI-538 Property

Boiling point:: 812.0±65.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (176.49 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 9.46±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6431
Product name: MI-538
Purity: 99.01%
Packaging: 10mg
Price: $504
Updated: 2021/12/16

ChemScene

Product number: CS-6431
Product name: MI-538
Purity: 99.01%
Packaging: 50mg
Price: $1380
Updated: 2021/12/16

ChemScene

Product number: CS-6431
Product name: MI-538
Purity: 99.01%
Packaging: 100mg
Price: $2340
Updated: 2021/12/16

DC Chemicals

Product number: DC10287
Product name: MI-538
Purity: >98%
Packaging: 1g
Price: $2500
Updated: 2021/12/16

DC Chemicals

Product number: DC10287
Product name: MI-538
Purity: >98%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

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MI-538 Chemical Properties,Usage,Production

Uses

MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM.

in vivo

Treatment with MI-538 results in a pronounced, about 80%, reduction in the MV4;11 tumor volume, without causing substantial signs of toxicity reflected by less than 10% reduction of the body weight. MI-538 demonstrates markedly improved exposure (area under the curve, AUC, values), Cmax (maximum compound concentration) in the blood plasma, and the lowest value of clearance. The half-life of MI-538 is about 1.6 h. MI-538 has also high oral bioavailability (~50%)^[1].

References

[1] Borkin D, et al. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016 Feb 11;59(3):892-913. DOI:10.1021/acs.jmedchem.5b01305

MI-538 Preparation Products And Raw materials

Raw materials

Preparation Products

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MI-538 Suppliers

China 33 United States 3 Global 36

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1857417-10-7, MI-538Related Search:

MI538; MI 538

MI-538

1H-Indole-2-carbonitrile, 6-hydroxy-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-

MI538,inhibit,Epigenetic Reader Domain,Inhibitor,MI-538,MI 538

1-((1H-pyrazol-4-yl)methyl)-6-hydroxy-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile

MI-538, 10 mM in DMSO

1857417-10-7

C27H25F3N8OS