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Copanlisib

Product Name
Copanlisib
CAS No.
1402152-13-9
Chemical Name
Copanlisib
Synonyms
Copanlisib HCl;Copanlisib HCI;Copanlisib.2HCl;4-Diaminotoluene;trade name Aliqopa.;copanlisib hydrochloride;BAY 80-6946 dihydrochloride;Copanlisib dihydrochloride (BAY 80-6946);2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide;COPANLISIB HCL; COPANLISIB DIHYDROCHLORIDE; BAY 80-6946; BAY80-6946; BAY-80-6946; BAY806946; BAY-806946; BAY 806946; COPANLISIB; TRADE NAME ALIQOPA.
CBNumber
CB23159884
Molecular Formula
C23H29ClN8O4
Formula Weight
516.99
MOL File
1402152-13-9.mol
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Copanlisib Property

solubility 
DMSO:1.0(Max Conc. mg/mL);2.08(Max Conc. mM)
Water:0.67(Max Conc. mg/mL);1.39(Max Conc. mM)
form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0030910
Product name
Copanlisibdihydrochloride
Purity
99.55%
Packaging
5mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-0030910
Product name
Copanlisibdihydrochloride
Purity
99.55%
Packaging
10mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0030910
Product name
Copanlisibdihydrochloride
Purity
99.55%
Packaging
50mg
Price
$270
Updated
2021/12/16
ChemScene
Product number
CS-0030910
Product name
Copanlisibdihydrochloride
Purity
99.55%
Packaging
100mg
Price
$450
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0005724
Product name
COPANLISIB DIHYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$453.92
Updated
2021/12/16
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Copanlisib Chemical Properties,Usage,Production

Uses

Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochloride has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib dihydrochloride has superior antitumor activity[1].

Definition

ChEBI: Copanlisib dihydrochloride is the dihydrochloride salt of copanlisib. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It contains a copanlisib.

in vivo

Copanlisib (BAY 80-6946; 0.5-6 mg/kg; intravenous injection; every second day, every third day; for 60 days; athymic nude rats) treatment displays robust antitumor activity in the rat KPL4 tumor xenograft model[1].

Animal Model:Athymic nude rats injected with KPL4 tumor cells[1]
Dosage:0.5 mg/kg, 1 mg/kg, 3 mg/kg or 6 mg/kg
Administration:Intravenous injection; every second day, every third day; for 60 days
Result: On day 25, tumor growth inhibition (TGI) rates of 77%, 84%, 99%, and 100% were observed at doses of 0.5, 1, 3, and 6 mg/kg, respectively. All rats remained tumor free at the termination of the study on day 73.

IC 50

PI3Kα: 0.5 nM (IC50); PI3Kδ: 0.7 nM (IC50); PI3Kβ: 3.7 nM (IC50); PI3Kγ: 6.4 nM (IC50); mTOP: 45 nM (IC50)

References

[1] Liu N, et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov;12(11):2319-30. DOI:10.1158/1535-7163.MCT-12-0993-T

Copanlisib Preparation Products And Raw materials

Raw materials

Preparation Products

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Copanlisib Suppliers

China 42 India 1 United States 3 USA 1 Global 47
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1150
Advantage
64
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7777
Advantage
56
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9532
Advantage
58
Hubei Yangxin Medical Technology Co., Ltd.
Tel
15374522761
Fax
QQ:2853117752
Email
3003392093@yongstandards.com
Country
China
ProdList
9999
Advantage
55
Heze Development Zone chuangli Chemical Co., Ltd.
Tel
0530-+86-530-529 6766，+86-15666160102 15666160102
Fax
0530-529 6766
Email
info@chuangli-chem.com
Country
China
ProdList
852
Advantage
55
Wuhan Sun-shine Bio-technology Corporation Limited
Tel
+86-027-6552-2453
Email
sales@sun-shinechem.com
Country
China
ProdList
727
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58

1402152-13-9, CopanlisibRelated Search:


  • Copanlisib HCl
  • copanlisib hydrochloride
  • Copanlisib HCI
  • 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide
  • Copanlisib.2HCl
  • COPANLISIB HCL; COPANLISIB DIHYDROCHLORIDE; BAY 80-6946; BAY80-6946; BAY-80-6946; BAY806946; BAY-806946; BAY 806946; COPANLISIB; TRADE NAME ALIQOPA.
  • trade name Aliqopa.
  • BAY 80-6946 dihydrochloride
  • Copanlisib dihydrochloride (BAY 80-6946)
  • 4-Diaminotoluene
  • 1402152-13-9
  • C23H30Cl2N8O4