ChemicalBook > CAS DataBase List > Trofinetide
Trofinetide
- Product Name
- Trofinetide
- CAS No.
- 853400-76-7
- Chemical Name
- Trofinetide
- Synonyms
- Trofinetide;prolyl-;NNZ-2566;Trofinetide (>90%);Trofinetide(NNZ2566);Glutamic acid, glycyl-TROFINETIDE; NNZ2566 ;NNZ 2566; NNZ-2566;L-Glutamic acid, glycyl-2-methyl-L-prolyl-;Trofinetide,NNZ 2566,NNZ2566,Inhibitor,inhibit;(S)-2-((S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carboxamido)pentanedioic acid
- CBNumber
- CB23159899
- Molecular Formula
- C13H21N3O6
- Formula Weight
- 315.32
- MOL File
- 853400-76-7.mol
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Trofinetide Property
- Melting point:
- 144 °C
- Boiling point:
- 655.4±55.0 °C(Predicted)
- Density
- 1.377±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- 3.51±0.10(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C13H21N3O6/c1-13(5-2-6-16(13)9(17)7-14)12(22)15-8(11(20)21)3-4-10(18)19/h8H,2-7,14H2,1H3,(H,15,22)(H,18,19)(H,20,21)/t8-,13-/m0/s1
- InChIKey
- BUSXWGRAOZQTEY-SDBXPKJASA-N
- SMILES
- C(O)(=O)[C@H](CCC(O)=O)NC(=O)[C@]1(C)CCCN1C(=O)CN
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N-Bromosuccinimide Price
TRC
- Product number
- T892525
- Product name
- Trofinetide
- Packaging
- 5mg
- Price
- $2310
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC11385
- Product name
- Trofinetide(NNZ2566)
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1100
- Updated
- 2021/12/16
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Trofinetide Chemical Properties,Usage,Production
Uses
Trofinetide is a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), that has shown to be neuroprotective in animal models of brain injury.
in vivo
Trofinetide (NNZ-2566) suppresses penetrating ballistic-like brain injury (PBBI) induced inflammatory cell infiltration at 3 days following PBBI as compare to vehicle treatment. Trofinetide treatment significantly reduces the elevation of IL-6 (79%), E-selectin (81%), IL-1β (76%) and TNF-α (72%) mRNA levels in the injured hemisphere at 12 h post-PBBI, with maximal inhibition occurring between 12 h and 24 h. Trofinetide treatment does not affect the PBBI-induced up-regulation of IL-6 expression at any time point, but does produce significant reductions in the injury-induced up-regulation of IL-1β, INF-γ, and TNF-α expression. Trofinetide treatment suppresses IL-1β expression in the injured brain hemisphere for up to 7 days post-PBBI[1]. The high doses of Trofinetide (NNZ-2566) (10 and 100 mg/kg bolus followed by continuous infusion) attenuate non-convulsive seizure (NCS) occurring beyond 2 h after permanent middle cerebral artery occlusion (pMCAo). All doses of Trofinetide completely suppress the delayed occurrence of NCS as compare with the vehicle-treated animals[2].
Trofinetide Preparation Products And Raw materials
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View Lastest Price from Trofinetide manufacturers
Jinan Ruitong Biotech Co., Ltd.
- Product
- Trofinetide
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-22