Pomalidomide-d5
- Product Name
- Pomalidomide-d5
- CAS No.
- 1377838-49-7
- Chemical Name
- Pomalidomide-d5
- Synonyms
- Pomalidomide-d5;4-Amino-2-(2,6-dioxopiperidin-3-yl-3,4,4,5,5-d5)isoindoline-1,3-dione
- CBNumber
- CB23163577
- Molecular Formula
- C13H11N3O4
- Formula Weight
- 273.25
- MOL File
- 1377838-49-7.mol
Pomalidomide-d5 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml,DMSO: 15 mg/ml
- form
- A solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25358
- Product name
- Pomalidomide-d5
- Purity
- ≥99% deuterated forms (d1-d5)
- Packaging
- 500μg
- Price
- $364
- Updated
- 2024/03/01
- Product number
- 25358
- Product name
- Pomalidomide-d5
- Purity
- ≥99% deuterated forms (d1-d5)
- Packaging
- 1mg
- Price
- $691
- Updated
- 2024/03/01
- Product number
- P688203
- Product name
- Pomalidomide-d5
- Packaging
- 1mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- P688203
- Product name
- Pomalidomide-d5
- Packaging
- 10mg
- Price
- $1585
- Updated
- 2021/12/16
- Product number
- 5113EG
- Product name
- 4-Amino-2-(3,4,4,5,5-pentadeuterio-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
- Packaging
- 1mg
- Price
- $866
- Updated
- 2021/12/16
Pomalidomide-d5 Chemical Properties,Usage,Production
Description
Pomalidomide-d5 is intended for use as an internal standard for the quantification of pomalidomide by GC- or LC-MS. Pomalidomide is an analog of thalidomide that inhibits the E3 ligase protein cereblon (CRBN) with an IC50 value of approximately 3 μM for the human recombinant CRBN-DNA damage binding protein-1 (CRBN-DDB1) complex. It inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN but not those expressing a thalidomide-binding defective CRBN mutation. It inhibits proliferation of U266 myeloma cells when used at concentrations ranging from 0.1 to 10 μM. Pomalidomide also has antiangiogenic and immunomodulatory effects against myeloma cells, modulating cell adhesion, decreasing production of key pro-survival cytokines, including TNF-α, and triggering the activation of caspase-8. Pomalidomide (3 mg/kg per day), in combination with dexamethasone, reduces tumor growth in a H929 R10-1 lenalidomide-resistant mouse xenograft model. Formulations containing pomalidomide have been used in the treatment of multiple myeloma.
Uses
Pomalidomide-d5 is the labeled analogue of Pomalidomide (P688200), a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
Pomalidomide-d5 Preparation Products And Raw materials
Raw materials
Preparation Products
Pomalidomide-d5 Suppliers
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- 025-85560043 13675144456
- Fax
- 025-85563444
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- China
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- 18012923235
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