Tarloxotinib bromide

Product Name: Tarloxotinib bromide
CAS No.: 1636180-98-7
Chemical Name: Tarloxotinib bromide
Synonyms: PR610;TH4000;PR 610;PR-610;TH-4000;Hypoxin;TH 4000;Tarloxotinib bromide;Tarloxotinib bromide，PR-610;Tarloxotinib bromide, 10 mM in DMSO
CBNumber: CB23165809
Molecular Formula: C24H24Br2ClN9O3
Formula Weight: 681.77
MOL File: 1636180-98-7.mol

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Tarloxotinib bromide Property

storage temp.: Store at -20°C
solubility: DMSO:30.0(Max Conc. mg/mL);44.0(Max Conc. mM)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T007610
Product name: TarloxotinibBromide
Packaging: 10mg
Price: $1320
Updated: 2021/12/16

ChemScene

Product number: CS-0016823
Product name: Tarloxotinib(bromide)
Purity: 98.97%
Packaging: 25mg
Price: $1500
Updated: 2021/12/16

ChemScene

Product number: CS-0016823
Product name: Tarloxotinib(bromide)
Purity: 98.97%
Packaging: 50mg
Price: $2100
Updated: 2021/12/16

ChemScene

Product number: CS-0016823
Product name: Tarloxotinib(bromide)
Purity: 98.97%
Packaging: 100mg
Price: $3300
Updated: 2021/12/16

ChemScene

Product number: CS-0016823
Product name: Tarloxotinib(bromide)
Purity: 98.97%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

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Tarloxotinib bromide Chemical Properties,Usage,Production

Uses

Tarloxotinib Bromide is a kinase inhibitor prodrug useful in the treatment of cancer.

in vivo

A prototypic WT EGFR driven xenograft model (A431) is used to benchmark Tarloxotinib bromide activity against each EGFR-TKI by “retrotranslation” of reported plasma exposure for each agent in human subjects back to the xenograft model. Only treatment with clinically relevant doses and schedules of Tarloxotinib bromide is associated with tumor regression and durable inhibition of WT EGFR tumor phosphorylation. Consistent with these findings, Tarloxotinib bromide treatment can also regress the WT EGFR NSCLC tumor models H125 and H1648, demonstrating Tarloxotinib bromide provides the necessary therapeutic index to inhibit WT EGFR in vivo^[1].

IC 50

EGFR/HER2

Tarloxotinib bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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Tarloxotinib bromide Suppliers

China 31 United States 3 Global 34

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15872
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9531
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 10408
Advantage: 58

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
Advantage: 58

1636180-98-7, Tarloxotinib bromideRelated Search:

Hypoxin

PR 610

PR610

PR-610

Tarloxotinib bromide

TH 4000

TH4000

TH-4000

Tarloxotinib bromide，PR-610

Tarloxotinib bromide,EGFR,Epidermal growth factor receptor,Inhibitor,TH 4000,ErbB-1,Tarloxotinib,HER1,inhibit,TH4000

Tarloxotinib bromide, 10 mM in DMSO

(E)-4-((4-((3-Bromo-4-chlorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)amino)-N,N-dimethyl-N-((1-methyl-4-nitro-1H-imidazol-5-yl)methyl)-4-oxobut-2-en-1-aminium bromide

1636180-98-7