RO6885247)

Product Name: RO6885247)
CAS No.: 1449598-06-4
Chemical Name: RO6885247)
Synonyms: RG7800;CS-2490;RO6885247);RG-7800; RG 7800;RG7800(RO6885247);RG7800( RO68852470;RG7800; RG-7800; RG 7800; RO6885247; RO-6885247; RO 6885247.;RG 7800,RO-6885247,RG-7800,Inhibitor,DNA/RNA Synthesis,RG7800,inhibit,RO 6885247;2-(4-Ethyl-6-methylpyrazolo[1,5-a]pyrazin-2-yl)-9-methyl-7-(1-methylpiperidin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one;4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-ethyl-6-methylpyrazolo[1,5-a]pyrazin-2-yl)-9-methyl-7-(1-methyl-4-piperidinyl)-
CBNumber: CB23169670
Molecular Formula: C24H28N6O
Formula Weight: 416.52
MOL File: 1449598-06-4.mol

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RO6885247) Property

Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:1.4(Max Conc. mg/mL);3.4(Max Conc. mM)
Ethanol:2.5(Max Conc. mg/mL);6.0(Max Conc. mM)
form: Solid
pka: 9.13±0.10(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6478
Product name: RG7800
Purity: 99.86%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-6478
Product name: RG7800
Purity: 99.86%
Packaging: 10mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-6478
Product name: RG7800
Purity: 99.86%
Packaging: 50mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-6478
Product name: RG7800
Purity: 99.86%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

DC Chemicals

Product number: DC10191
Product name: RG7800
Purity: >98%
Packaging: 250mg
Price: $800
Updated: 2021/12/16

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RO6885247) Chemical Properties,Usage,Production

Uses

RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.

in vivo

RG7800 shows favorable drug metabolism and pharmacokinetic profile in the rat and in cynomolgus monkey with good oral bioavailability. In SMA mouse model, treatment of RG7800 shows a clear dose dependent increase in SMN protein levels. Mice treated with RG7800 demonstrate a dose dependent increase in survival beginning at the low dose (0.3/1 mg/kg). In the middle and high dose groups (1/3 and 3/10 mg/kg, respectively), approximately 80 90% survive beyond PND50/PND60 with profound body weight gain when the study is terminated. RG7800 dose-dependently corrects SMN2 splicing by including exon 7 to create FL mRNA, suggesting that RG7800 corrects alternative splicing of the human SMN2 gene in the brain of transgenic SMA model mice, leading to an increase of the SMN protein in the brain^[1].

References

[1] Ratni H, et al. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy. J Med Chem. 2016 Jul 14;59(13):6086-100. DOI:10.1021/acs.jmedchem.6b00459

RO6885247) Preparation Products And Raw materials

Raw materials

Preparation Products

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RO6885247) Suppliers

China 41 United States 5 Global 46

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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TargetMol Chemicals Inc.

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1449598-06-4, RO6885247)Related Search:

RG7800

RO6885247)

RG7800(RO6885247)

RG-7800; RG 7800

CS-2490

RG7800; RG-7800; RG 7800; RO6885247; RO-6885247; RO 6885247.

4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-ethyl-6-methylpyrazolo[1,5-a]pyrazin-2-yl)-9-methyl-7-(1-methyl-4-piperidinyl)-

2-(4-Ethyl-6-methylpyrazolo[1,5-a]pyrazin-2-yl)-9-methyl-7-(1-methylpiperidin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

RG7800( RO68852470

RG 7800,RO-6885247,RG-7800,Inhibitor,DNA/RNA Synthesis,RG7800,inhibit,RO 6885247

1449598-06-4