RO6885247)
- Product Name
- RO6885247)
- CAS No.
- 1449598-06-4
- Chemical Name
- RO6885247)
- Synonyms
- RG7800;CS-2490;RO6885247);RG-7800; RG 7800;RG7800(RO6885247);RG7800( RO68852470;RG7800; RG-7800; RG 7800; RO6885247; RO-6885247; RO 6885247.;RG 7800,RO-6885247,RG-7800,Inhibitor,DNA/RNA Synthesis,RG7800,inhibit,RO 6885247;2-(4-Ethyl-6-methylpyrazolo[1,5-a]pyrazin-2-yl)-9-methyl-7-(1-methylpiperidin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one;4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-ethyl-6-methylpyrazolo[1,5-a]pyrazin-2-yl)-9-methyl-7-(1-methyl-4-piperidinyl)-
- CBNumber
- CB23169670
- Molecular Formula
- C24H28N6O
- Formula Weight
- 416.52
- MOL File
- 1449598-06-4.mol
RO6885247) Property
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:1.4(Max Conc. mg/mL);3.4(Max Conc. mM)
Ethanol:2.5(Max Conc. mg/mL);6.0(Max Conc. mM) - form
- Solid
- pka
- 9.13±0.10(Predicted)
- color
- Off-white to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-6478
- Product name
- RG7800
- Purity
- 99.86%
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-6478
- Product name
- RG7800
- Purity
- 99.86%
- Packaging
- 10mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CS-6478
- Product name
- RG7800
- Purity
- 99.86%
- Packaging
- 50mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- CS-6478
- Product name
- RG7800
- Purity
- 99.86%
- Packaging
- 100mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- DC10191
- Product name
- RG7800
- Purity
- >98%
- Packaging
- 250mg
- Price
- $800
- Updated
- 2021/12/16
RO6885247) Chemical Properties,Usage,Production
Uses
RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.
in vivo
RG7800 shows favorable drug metabolism and pharmacokinetic profile in the rat and in cynomolgus monkey with good oral bioavailability. In SMA mouse model, treatment of RG7800 shows a clear dose dependent increase in SMN protein levels. Mice treated with RG7800 demonstrate a dose dependent increase in survival beginning at the low dose (0.3/1 mg/kg). In the middle and high dose groups (1/3 and 3/10 mg/kg, respectively), approximately 80 90% survive beyond PND50/PND60 with profound body weight gain when the study is terminated. RG7800 dose-dependently corrects SMN2 splicing by including exon 7 to create FL mRNA, suggesting that RG7800 corrects alternative splicing of the human SMN2 gene in the brain of transgenic SMA model mice, leading to an increase of the SMN protein in the brain[1].
References
[1] Ratni H, et al. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy. J Med Chem. 2016 Jul 14;59(13):6086-100. DOI:10.1021/acs.jmedchem.6b00459
RO6885247) Preparation Products And Raw materials
Raw materials
Preparation Products
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