Mavacamten
- Product Name
- Mavacamten
- CAS No.
- 1642288-47-8
- Chemical Name
- Mavacamten
- Synonyms
- YMK-461;MYK-461 (SAR-439152);MYK-461;SAR439152;Mawakatan;SAR-439152;SAR 439152;Mavacamten;Mavacampten;Mava Kaitai
- CBNumber
- CB23170382
- Molecular Formula
- C15H19N3O2
- Formula Weight
- 273.33
- MOL File
- 1642288-47-8.mol
Mavacamten Property
- Density
- 1.19±0.1 g/cm3(Predicted)
- solubility
- insoluble in H2O; ≥11.32 mg/mL in EtOH with ultrasonic; ≥13.65 mg/mL in DMSO
- form
- solid
- pka
- 8.83±0.40(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1
- InChIKey
- RLCLASQCAPXVLM-NSHDSACASA-N
- SMILES
- C1(=O)NC(N[C@H](C2=CC=CC=C2)C)=CC(=O)N1C(C)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 19216
- Product name
- MYK-461
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 19216
- Product name
- MYK-461
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- 19216
- Product name
- MYK-461
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- A8720
- Product name
- MYK-461
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $310
- Updated
- 2021/12/16
- Product number
- CS-0031211
- Product name
- Mavacamten
- Purity
- 99.94%
- Packaging
- 25mg
- Price
- $330
- Updated
- 2021/12/16
Mavacamten Chemical Properties,Usage,Production
Description
Mavacamten（MYK-461）is a first-in-class allosteric inhibitor of cardiac myosin that promises to provide clinicians with targeted therapy for these patients. It is a mechanistically novel small molecule that acts on the sarcolemma to specifically inhibit contractility and has been proposed as a treatment for HCM.
Uses
MYK-461 is a drug used to treat obstructive hypertrophic cardiomyopathy as a cardiac myosin inhibitor. Mavacamten is used to treat adults with symptomatic obstructive hypertrophic cardiomyopathy. It is used to treat symptomatic obstructive hypertrophic cardiomyopathy (HCM).
Mechanism of action
Mavacamten is thought to work by reducing cardiac muscle contractility by inhibiting excessive myosin-actin cross-bridge formation that results in hypercontractility, left ventricular hypertrophy and reduced compliance. In clinical and preclinical studies, it has consistently reduced biomarkers of cardiac wall stress, lessened excessive cardiac contractility, and increased diastolic compliance.
Side effects
Common side effects include:Dizziness, fainting, Incidence not known, Chest pain or tightness, decreased urine output, dilated neck veins, irregular breathing, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, unusual tiredness or weakness and weight gain.
Mavacamten Preparation Products And Raw materials
Raw materials
Preparation Products
Mavacamten Suppliers
View Lastest Price from Mavacamten manufacturers
- Product
- MYK-461 (SAR-439152) 1642288-47-8
- Price
- US $0.00-0.00/g
- Min. Order
- 10000g
- Purity
- 99% HPLC
- Supply Ability
- 1000kg
- Release date
- 2024-09-12
- Product
- Mavacamten 1642288-47-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.82%
- Supply Ability
- 1000g
- Release date
- 2024-10-29
- Product
- Mavacamten 1642288-47-8
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-07-19