ChemicalBook > CAS DataBase List > ISOFAGOMINE, HYDROCHLORIDE

ISOFAGOMINE, HYDROCHLORIDE

Product Name: ISOFAGOMINE, HYDROCHLORIDE
CAS No.: 169105-89-9
Chemical Name: ISOFAGOMINE, HYDROCHLORIDE
Synonyms: Afegostat;D-Isofagomine;Unii-G23ap190ys;IsofagomineHydrochlroide;SOFAGOMINE, HYDROCHLORIDE;ISOFAGOMINE, HYDROCHLORIDE;5-Hydroxymethyl-3,4-piperidinediol;5-(HYDROXYMETHYL)PIPERIDINE-3,4-DIOL;(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol;3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)-
CBNumber: CB2317412
Molecular Formula: C6H13NO3
Formula Weight: 147.17
MOL File: 169105-89-9.mol

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ISOFAGOMINE, HYDROCHLORIDE Property

Boiling point:: 317.2±37.0 °C(Predicted)
Density: 1.279±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: Soluble in DMSO
pka: 14.19±0.60(Predicted)
form: Oil
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: I816015
Product name: Isofagomine
Packaging: 25mg
Price: $685
Updated: 2021/12/16

Biosynth Carbosynth

Product number: MI45273
Product name: Isofagomine hydrochloride
Packaging: 100mg
Price: $2900
Updated: 2021/12/16

AHH

Product number: MT-16041
Product name: Isofagominehydrochloride
Purity: 98%
Packaging: 0.005g
Price: $338
Updated: 2021/12/16

Crysdot

Product number: CD11239950
Product name: (3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol
Purity: 95+%
Packaging: 5g
Price: $1200
Updated: 2021/12/16

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ISOFAGOMINE, HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Yellow Low-Melting Solid

Uses

A selective and very strong inhibitor of ?Glucosidase (Ki0.11uM)

Uses

Isofagomine is a selective Inhibitor of β-Glycosidases.

Definition

ChEBI: Afegostat is a member of piperidines.

in vivo

Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates^[1].

ISOFAGOMINE, HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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169105-89-9, ISOFAGOMINE, HYDROCHLORIDERelated Search:

N,N-DIETHYLBENZAMIDE 2-Methylindole ISOFAGOMINE, HYDROCHLORIDE

ISOFAGOMINE, HYDROCHLORIDE

(3R,4R,5R)-5-(HYDROXYMETHYL)-3,4-PIPERIDINEDIOL, HYDROCHLORIDE

SOFAGOMINE, HYDROCHLORIDE

5-(HYDROXYMETHYL)PIPERIDINE-3,4-DIOL

(3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol,HCl

IsofagomineHydrochlroide

(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol

3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)-

5-Hydroxymethyl-3,4-piperidinediol

Afegostat

D-Isofagomine

Unii-G23ap190ys

(3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol hydrochloride

169105-89-9

pharmacetical

Inhibitors