ChemicalBook > CAS DataBase List > 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID

1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID

Product Name
1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
CAS No.
10250-64-3
Chemical Name
1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
Synonyms
5-Carboxy-1-methyl-3-phenyl-1H-pyrazole;2-methyl-5-phenyl-pyrazole-3-carboxylic acid;2-Methyl-5-phenyl-2H-pyrazole-3-carboxylic acid;1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID;1H-Pyrazole-5-carboxylic acid, 1-methyl-3-phenyl-;1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid 97%;1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid 95+%;1-methyl-3-phenyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE)
CBNumber
CB2329217
Molecular Formula
C11H10N2O2
Formula Weight
202.21
MOL File
10250-64-3.mol
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1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID Property

Melting point:
186 °C
Boiling point:
419.6±33.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
form 
solid
pka
2.97±0.25(Predicted)
color 
White
CAS DataBase Reference
10250-64-3
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
WGK Germany 
3
HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
JRD0070
Product name
1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid
Purity
Aldrich
Packaging
1g
Price
$185
Updated
2025/07/31
TRC
Product number
B400415
Product name
1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid
Packaging
50mg
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
OR3884
Product name
1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid
Packaging
1g
Price
$125
Updated
2021/12/16
Apolloscientific
Product number
OR3884
Product name
1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid
Packaging
5g
Price
$415
Updated
2021/12/16
SynQuest Laboratories
Product number
4H21-1-5F
Product name
1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid
Purity
97%
Packaging
5G
Price
$492
Updated
2021/12/16
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1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

10250-62-1

10250-64-3

The general procedure for the synthesis of 1-methyl-3-phenyl-1H-pyrazole-5-carboxylic acid from methyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate was as follows: 1-methyl-3-phenyl-1H-pyrazole-5-carboxylic acid methyl ester (1.00 g, 6.23 mmol) was dissolved in a mixed solvent of ethanol (10 mL) and water (10 mL), and then lithium hydroxide mono hydrate (0.582 g, 13.87 mmol). The reaction mixture was stirred at 50 °C until the reaction was complete as monitored by high performance liquid chromatography (HPLC). After completion of the reaction, the mixture was concentrated to dryness and the residue was dissolved in water and extracted with dichloromethane (DCM). The aqueous phase was acidified with 1N hydrochloric acid to pH < 3. The precipitated solid was collected by filtration and dried under high vacuum to afford 1-methyl-3-phenyl-1H-pyrazole-5-carboxylic acid (0.887 g, 95% yield) as a white solid. The mass spectrum (APCI positive ion mode) showed m/z 203 (100%) ([M+H]+).

References

[1] Patent: WO2008/11131, 2008, A2. Location in patent: Page/Page column 260
[2] Chemische Berichte, 1933, vol. 66, p. 1690,1692
[3] Patent: EP1176140, 2002, A1. Location in patent: Page 49 - 50

1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID Suppliers

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10250-64-3, 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACIDRelated Search:

ETHYL 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE 1-METHYL-5-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID,1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid 97% 1-METHYL-5-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 5-METHYL-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER ETHYL 3-(4-BROMOPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE 2-(4-FLUORO-PHENYL)-5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL 1-(2,5-DICHLOROBENZYL)-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE ETHYL 1-BENZYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE ETHYL 3-(4-METHOXYPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE ETHYL 1-METHYL-3-P-TOLYL-1H-PYRAZOLE-5-CARBOXYLATE ETHYL 1-(4-FLUOROBENZYL)-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE 2,5-DIPHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 2-(4-BROMO-PHENYL)-5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL 1-(4-CHLOROBENZYL)-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLATE 2-(4-CHLORO-PHENYL)-5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID 2-(4-METHOXY-PHENYL)-5-PHENYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

  • 1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
  • 1-methyl-3-phenyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE)
  • 5-Carboxy-1-methyl-3-phenyl-1H-pyrazole
  • 1H-Pyrazole-5-carboxylic acid, 1-methyl-3-phenyl-
  • 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid 97%
  • 2-Methyl-5-phenyl-2H-pyrazole-3-carboxylic acid
  • 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid 95+%
  • 2-methyl-5-phenyl-pyrazole-3-carboxylic acid
  • 10250-64-3