4-CYCLOPROPYL-BENZOIC ACID

Product Name: 4-CYCLOPROPYL-BENZOIC ACID
CAS No.: 1798-82-9
Chemical Name: 4-CYCLOPROPYL-BENZOIC ACID
Synonyms: AKOS BAR-1173;4-CYCLOPROPYL-BENZOIC ACID;Benzoic acid, 4-cyclopropyl-
CBNumber: CB2329479
Molecular Formula: C10H10O2
Formula Weight: 162.19
MOL File: 1798-82-9.mol

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4-CYCLOPROPYL-BENZOIC ACID Property

Melting point:: 221-224°C
Boiling point:: 305.8±21.0 °C(Predicted)
Density: 1.248±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 4.41±0.10(Predicted)
color: Off-white

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC75991
Product name: 4-Cyclopropylbenzoic acid
Packaging: 50mg
Price: $130
Updated: 2021/12/16

Apolloscientific

Product number: OR451110
Product name: 4-Cyclopropyl-benzoicacid
Packaging: 250mg
Price: $131
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC75991
Product name: 4-Cyclopropylbenzoic acid
Packaging: 25mg
Price: $80
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2721-1-0R
Product name: 4-Cyclopropylbenzoic acid
Packaging: 250mg
Price: $144
Updated: 2021/12/16

Apolloscientific

Product number: OR451110
Product name: 4-Cyclopropyl-benzoicacid
Packaging: 1g
Price: $240
Updated: 2021/12/16

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4-CYCLOPROPYL-BENZOIC ACID Chemical Properties,Usage,Production

Uses

4-Cyclopropylbenzoic Acid in a component in the perpetration of Bruton''s Tyrosine Kinase Inhibitors.

Synthesis

500-05-0

6746-94-7

1798-82-9

Example 8 Synthesis of 4-(2-guanidinothiazol-4-yl)phenyl 4-cyclopropyl benzoate (13f) Procedure:(a) Preparation of 4-cyclopropyl benzoate. Coumaric acid (2.63 g, 18.74 mmol) was mixed with cyclopropyl acetylene (1.24 g, 18.74 mmol) in diethylene glycol dimethyl ether and the reaction mixture was refluxed for 36 hours. After completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The resulting crude product was recrystallized in ethanol (EtOH) to give 1.26 g of 4-cyclopropylbenzoic acid in 42% yield. The product was characterized as follows: 1HNMR (DMSO-d6): δ7.81 (d, J=8.4 Hz, 2H), 7.16 (d, J=8.4 Hz, 2H), 1.97 (sept, J=5.1 Hz, 1H), 1.01 (m, 2H), 0.74 (m, 2H). 13CNMR (DMSO-d6): δ167.24 ,149.51,129.32,127.65,125.19,15.25,10.37.

References

[1] Patent: WO2009/146013, 2009, A1. Location in patent: Page/Page column 61

4-CYCLOPROPYL-BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CYCLOPROPYL-BENZOIC ACID Suppliers

China 67 Germany 2 India 2 Russia 1 United Kingdom 4 United States 10 Global 86

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View Lastest Price from 4-CYCLOPROPYL-BENZOIC ACID manufacturers

Career Henan Chemical Co

Product: 4-CYCLOPROPYL-BENZOIC ACID 1798-82-9
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

1798-82-9, 4-CYCLOPROPYL-BENZOIC ACIDRelated Search:

4-(2,2-DIMETHYL-CYCLOPROPYL)-BENZOIC ACID 4-(1-METHYL-CYCLOPROPYL)-BENZOIC ACID 2-[2-(Methoxycarbonyl)cyclopropyl]benzoic acid methyl ester 4-(2,2-DICHLORO-CYCLOPROPYL)-BENZOIC ACID METHYL 4-CYCLOPROPYLBENZOATE METHYL 4-(2-CHLOROCYCLOPROPYL)BENZOATE 4-CYCLOPROPYL-BENZOIC ACID 4-(1-AMINOCYCLOPROPYL)BENZOIC ACID

4-CYCLOPROPYL-BENZOIC ACID

AKOS BAR-1173

Benzoic acid, 4-cyclopropyl-

1798-82-9