HS-PEG5-CH2CH2N3

Product Name: HS-PEG5-CH2CH2N3
CAS No.: 1449390-11-7
Chemical Name: HS-PEG5-CH2CH2N3
Synonyms: Azido-PEG5-Thiol;HS-PEG5-CH2CH2N3;17-azido-3,6,9,12,15-pentaoxaheptadecane-1-thiol;2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanethiol
CBNumber: CB23309438
Molecular Formula: C12H25N3O5S
Formula Weight: 323.41
MOL File: 1449390-11-7.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

purepeg

Product number: 434705
Product name: HS-PEG5-CH2CH2N3
Purity: min.95%
Packaging: 250mg
Price: $350
Updated: 2021/12/16

purepeg

Product number: 434705
Product name: HS-PEG5-CH2CH2N3
Purity: min.90%
Packaging: 1g
Price: $650
Updated: 2021/12/16

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HS-PEG5-CH2CH2N3 Chemical Properties,Usage,Production

Uses

HS-PEG5-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. HS-PEG5-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Biological Activity

HS-PEG5-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

HS-PEG5-CH2CH2N3 Preparation Products And Raw materials

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HS-PEG5-CH2CH2N3 Suppliers

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Alfa Chemistry

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PurePEG，LLC

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1449390-11-7, HS-PEG5-CH2CH2N3Related Search:

HS-PEG5-CH2CH2COOH Thiol-PEG5-phosphonic acid Thiol-PEG5-t-butyl ester HS-PEG5-OH

HS-PEG5-CH2CH2N3

Azido-PEG5-Thiol

2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanethiol

17-azido-3,6,9,12,15-pentaoxaheptadecane-1-thiol

1449390-11-7