Nelonicline
- Product Name
- Nelonicline
- CAS No.
- 1026134-63-3
- Chemical Name
- Nelonicline
- Synonyms
- ABT-126;Nelonicline;Nelonicline（ABT-126）;2-(((3R,4r,5S,7s)-1-azaadamantan-4-yl)oxy)-5-phenyl-1,3,4-thiadiazole;1-Azatricyclo[3.3.1.13,7]decane, 4-[(5-phenyl-1,3,4-thiadiazol-2-yl)oxy]-, stereoisomer
- CBNumber
- CB23310337
- Molecular Formula
- C17H19N3OS
- Formula Weight
- 313.42
- MOL File
- 1026134-63-3.mol
Nelonicline Property
- Boiling point:
- 460.2±55.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 7.78±0.40(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- DC11247
- Product name
- Nelonicline
- Purity
- >98%
- Packaging
- 250mg
- Price
- $990
- Updated
- 2021/12/16
- Product number
- DC11247
- Product name
- Nelonicline
- Purity
- >98%
- Packaging
- 1g
- Price
- $1900
- Updated
- 2021/12/16
Nelonicline Chemical Properties,Usage,Production
Uses
Nelonicline (ABT-126) is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (Ki=12.3 nM). Nelonicline is used for the research of shizophrenia and Alzheimer's disease[1][2][3].
References
[1] Zhang D, et al. α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage. Mov Disord. 2015;30(14):1901-1911. DOI:10.1002/mds.26453
[2] Haig G, et al. The α7 Nicotinic Agonist ABT-126 in the Treatment of Cognitive Impairment Associated with Schizophrenia in Nonsmokers: Results from a Randomized Controlled Phase 2b Study. Neuropsychopharmacology. 2016;41(12):2893-2902. DOI:10.1038/npp.2016.101
[3] Gault LM, et al. ABT-126 monotherapy in mild-to-moderate Alzheimer's dementia: randomized double-blind, placebo and active controlled adaptive trial and open-label extension. Alzheimers Res Ther. 2016;8(1):44. Published 2016 Oct 18. DOI:10.1186/s13195-016-0210-1
Nelonicline Preparation Products And Raw materials
Raw materials
Preparation Products
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