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2'2'-cGAMP

Product Name
2'2'-cGAMP
CAS No.
1465774-27-9
Chemical Name
2'2'-cGAMP
Synonyms
2’2’-cGAMP;2'2'-cGAMP;2’2’-cGAMP (sodium salt);2'2'-cGAMP (sodium salt);c[A(2′,,5′,)pG(2′,,5′,)p];2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide;adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt
CBNumber
CB23311738
Molecular Formula
C20H24N10O13P2
Formula Weight
674.411
MOL File
1465774-27-9.mol
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2'2'-cGAMP Property

Boiling point:
1159.9±75.0 °C(Predicted)
Density 
2.61±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Water: soluble
form 
A crystalline solid
pka
0.88±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22419
Product name
2’2’-cGAMP (sodium salt)
Packaging
500μg
Price
$422
Updated
2024/03/01
Cayman Chemical
Product number
22419
Product name
2’2’-cGAMP (sodium salt)
Packaging
1mg
Price
$714
Updated
2024/03/01
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2'2'-cGAMP Chemical Properties,Usage,Production

Description

2’2’-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes (STING; Item Nos. 22816 | 22815), which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2’2-cGAMP shows weaker binding to STING than 2’3’-cGAMP (; Kd = 287 and 3.79 nM, respectively) but binds more strongly than 3’3’-cGAMP , cyclic di-GMP , or 3’2’-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2’2’-cGAMP induces IFN-β production in the same concentration range as 2’3’-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).

Uses

2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP binds weaker binding to STING than 2'3'-cGAMP (HY-100564) but stronger than other CDNs[1].

References

[1] Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013;51(2):226-235. DOI:10.1016/j.molcel.2013.05.022

2'2'-cGAMP Preparation Products And Raw materials

Raw materials

Preparation Products

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2'2'-cGAMP Suppliers

China 10 United States 4 Global 14
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5929
Advantage
58
Shanghai Fine Biotech Co.，Ltd
Tel
18221172427
Email
sale@fine-biotech.com
Country
China
ProdList
2753
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Enzo Biochem Inc
Tel
Enzo Biochem Inc. 13797054060
Email
Enzoname@qq.com
Country
China
ProdList
6174
Advantage
58

1465774-27-9, 2'2'-cGAMPRelated Search:


  • 2'2'-cGAMP
  • 2’2’-cGAMP (sodium salt)
  • 2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide
  • adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt
  • 2'2'-cGAMP (sodium salt)
  • 2’2’-cGAMP
  • c[A(2&#8242,,5&#8242,)pG(2&#8242,,5&#8242,)p]
  • 1465774-27-9