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2'2'-cGAMP

Product Name
2'2'-cGAMP
CAS No.
1465774-27-9
Chemical Name
2'2'-cGAMP
Synonyms
2’2’-cGAMP;2'2'-cGAMP;2’2’-cGAMP (sodium salt);2'2'-cGAMP (sodium salt);2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide;adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt;adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt
CBNumber
CB23311738
Molecular Formula
C20H24N10O13P2
Formula Weight
674.411
MOL File
1465774-27-9.mol
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2'2'-cGAMP Property

Boiling point:
1159.9±75.0 °C(Predicted)
Density 
2.61±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Water: soluble
form 
A crystalline solid
pka
0.88±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22419
Product name
2’2’-cGAMP (sodium salt)
Packaging
500μg
Price
$422
Updated
2024/03/01
Cayman Chemical
Product number
22419
Product name
2’2’-cGAMP (sodium salt)
Packaging
1mg
Price
$714
Updated
2024/03/01
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2'2'-cGAMP Chemical Properties,Usage,Production

Description

2’2’-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes (STING; Item Nos. 22816 | 22815), which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2’2-cGAMP shows weaker binding to STING than 2’3’-cGAMP (; Kd = 287 and 3.79 nM, respectively) but binds more strongly than 3’3’-cGAMP , cyclic di-GMP , or 3’2’-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2’2’-cGAMP induces IFN-β production in the same concentration range as 2’3’-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).

2'2'-cGAMP Preparation Products And Raw materials

Raw materials

Preparation Products

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2'2'-cGAMP Suppliers

China 7 United States 4 Global 11
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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14055
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BOC Sciences
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+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
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United States
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BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
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6213
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1465774-27-9, 2'2'-cGAMPRelated Search:


  • 2'2'-cGAMP
  • 2’2’-cGAMP (sodium salt)
  • 2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide
  • adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt
  • 2'2'-cGAMP (sodium salt)
  • 2’2’-cGAMP
  • adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt
  • 1465774-27-9