H-ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN-OH

Product Name: H-ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN-OH
CAS No.: 211439-12-2
Chemical Name: H-ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN-OH
Synonyms: NAP;Davunetide;NAPVSIPQ;ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN;P14L;AL 108;AL 208;AL-108;AL-208;PP8304
CBNumber: CB2333238
Molecular Formula: C36H60N10O12
Formula Weight: 824.92
MOL File: Mol file

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H-ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN-OH Property

storage temp.: -15°C
solubility: DMSO:1.0(Max Conc. mg/mL);1.21(Max Conc. mM)
form: Solid
color: White to off-white
Water Solubility: Soluble to 1 mg/ml in water
Sequence: H-Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln-OH

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2063
Product name: Davunetide trifluoroacetate salt
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $91.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2063
Product name: Davunetide trifluoroacetate salt
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $371
Updated: 2025/07/31

Tocris

Product number: 6779
Product name: Davunetide
Purity: ≥95%(HPLC)
Packaging: 1
Price: $65
Updated: 2021/12/16

TRC

Product number: N325008
Product name: NAP
Packaging: 5mg
Price: $495
Updated: 2021/12/16

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H-ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN-OH Chemical Properties,Usage,Production

Uses

NAP is a neuroprotective peptide. It can also be used in biological study of integrating network, sequence and functional features using machine learning approaches towards identification of novel Alzheimer genes.

Definition

ChEBI: Davunetide is an oligopeptide.

Biological Activity

Davunetide (NAPVSIPQ; NAP) is an eight amino acid peptide identified as the active component of activity-dependent neuroprotective protein (ADNP). It has been found to be neuro-protective at femtomolar concentrations in vitro against the neural toxicity of a wide range of compounds. Davunetide has been investigated for Parkinsonμs disease and schizophrenia and in clinical trials for Alzheimnerμs Disease, targeting microtubule-tau Interaction.

in vivo

Davunetide (2 μg/kg; Intranasally; daily, 5 days a week, for 16 weeks) shows protective effects for central nervous system complications in a diabetes rat model^[3].

Animal Model:	Male Sprague-Dawley rats (Induced by an i.p. streptozotocin (STZ) injection)^[3]
Dosage:	2 μg/kg
Administration:	Intranasally beginning on the day following the STZ injection and were given daily, 5 days a week, for 16 weeks
Result:	Impaired spatial memory of the diabetic rats was observed in the water maze by attenuated learning curve and worsened performance in the probe memory test. Davunetide treatment significantly improved both measurements.

storage

Store at -20°C

H-ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN-OH Suppliers

China 80 Germany 1 United States 11 Global 92

GL Biochem (Shanghai) Ltd

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211439-12-2, H-ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN-OHRelated Search:

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ACTIVITY-DEPENDENT NEUROPROTECTIVE PROTEIN FRAGMENT 74-81, MOUSE, RAT;ADNP [74-81]

Davunetide

H2N-NAPVSIPQ-OH

H-ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN-OH

ACTIVITY-DEPENDENT NEUROPROTECTIVE PROTEIN (74-81) (MOUSE, RAT)

ACTIVITY-DEPENDENT NEUROPROTECTOR (ADNP) FRAGMENT [HOMO SAPIENS]/[MUS MUSCULUS]/[RATTUS NORVEGICUS]

NAP (MOUSE, RAT)

NAPVSIPQ

NAP

ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN

ADNP [74-81]

Davunetide,NAP

AL 108

AL 208

AL-108

AL-208

Davunetide trifluoroacetate salt

NAP,Davunetide

C20orf33

dJ633O20.1

P14L

PP8304

211439-12-2

C36H160N10O12

C36H60N10O12

Peptide