Nicodicosapent

Product Name: Nicodicosapent
CAS No.: 1269181-69-2
Chemical Name: Nicodicosapent
Synonyms: Nicodicosapent;3-Pyridinecarboxamide, N-[2-[[(5Z,8Z,11Z,14Z,17Z)-1-oxo-5,8,11,14,17-eicosapentaen-1-yl]amino]ethyl]-
CBNumber: CB23333738
Molecular Formula: C28H39N3O2
Formula Weight: 449.63
MOL File: 1269181-69-2.mol

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Nicodicosapent Property

Boiling point:: 677.5±55.0 °C(Predicted)
Density: 1.013±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 100 mg/mL (222.41 mM); Ethanol: 2 mg/mL (4.45 mM); Water: < 0.1 mg/mL (insoluble)
form: Solid
pka: 13.26±0.46(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7484
Product name: Nicodicosapent
Purity: 98.09%
Packaging: 2mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-7484
Product name: Nicodicosapent
Purity: 98.09%
Packaging: 5mg
Price: $216
Updated: 2021/12/16

ChemScene

Product number: CS-7484
Product name: Nicodicosapent
Purity: 98.09%
Packaging: 10mg
Price: $360
Updated: 2021/12/16

ChemScene

Product number: CS-7484
Product name: Nicodicosapent
Purity: 98.09%
Packaging: 50mg
Price: $1080
Updated: 2021/12/16

ChemScene

Product number: CS-7484
Product name: Nicodicosapent
Purity: 98.09%
Packaging: 100mg
Price: $1800
Updated: 2021/12/16

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Nicodicosapent Chemical Properties,Usage,Production

Uses

Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

in vivo

Nicodicosapent (100 mg/kg po) produces high plasma levels of nicotinuric acid in the plasma. ApoE*3-Leiden mice treated with Nicodicosapent show a significant reduction in PCSK9 levels, LDL particles including VLDL and LDL cholesterol, as well as plasma triglycerides^[1].

References

[1] Vu CB, et al. Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid. J Med Chem. 2016 Feb 11;59(3):1217-31. DOI:10.1021/acs.jmedchem.5b01961

Nicodicosapent Preparation Products And Raw materials

Raw materials

Preparation Products

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Nicodicosapent Suppliers

China 15 United States 5 Global 20

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1269181-69-2, NicodicosapentRelated Search:

Nicodicosapent

3-Pyridinecarboxamide, N-[2-[[(5Z,8Z,11Z,14Z,17Z)-1-oxo-5,8,11,14,17-eicosapentaen-1-yl]amino]ethyl]-

1269181-69-2