2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE

Product Name: 2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE
CAS No.: 4278-08-4
Chemical Name: 2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE
Synonyms: DK7411;868764;2-(4-Fluorophenyl)imidazole;2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE
CBNumber: CB2333405
Molecular Formula: C9H7FN2
Formula Weight: 162.16
MOL File: 4278-08-4.mol

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2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE Property

Melting point:: 196-198 °C
Boiling point:: 332.2±25.0 °C(Predicted)
Density: 1.242±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 12.90±0.10(Predicted)

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Safety

Risk Statements: 41
Safety Statements: 26-39
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F596403
Product name: 2-(4-Fluoro-phenyl)-1h-imidazole
Packaging: 50mg
Price: $55
Updated: 2021/12/16

TRC

Product number: F596403
Product name: 2-(4-Fluoro-phenyl)-1h-imidazole
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC402015
Product name: 2-(4-Fluorophenyl)-1H-imidazole
Packaging: 250mg
Price: $110
Updated: 2021/12/16

Apolloscientific

Product number: PC402015
Product name: 2-(4-Fluorophenyl)-1H-imidazole
Packaging: 1g
Price: $235
Updated: 2021/12/16

AK Scientific

Product number: 5900AB
Product name: 2-(4-Fluorophenyl)-1H-imidazole
Packaging: 250mg
Price: $126
Updated: 2021/12/16

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2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE Chemical Properties,Usage,Production

Synthesis

165901-26-8

4278-08-4

2-Aryl-4,5-dihydro-1H-imidazole (14b, x, 35 mmol) was used as the starting material and potassium carbonate (38.5 mmol) and diacetoxyiodobenzene (38.5 mmol) were added sequentially in DMSO (100 mL). The reaction mixture was placed in a dark environment and stirred overnight. Upon completion of the reaction, the reaction was quenched by the addition of water and the product was extracted with dichloromethane. The organic layers were combined, dried with magnesium sulfate and concentrated under reduced pressure to remove the solvent. The resulting residue was purified by fast column chromatography (eluent: hexane/ethyl acetate, 3:2, v/v) to afford 2-(4-fluorophenyl)-1H-imidazole as a white solid. Yield: 30%-50%.

References

[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 20, p. 7414 - 7427
[2] Patent: WO2011/109059, 2011, A1. Location in patent: Paragraph 0040; 00354
[3] Patent: WO2014/138279, 2014, A1. Location in patent: Paragraph 00221; 00246
[4] Journal of the American Chemical Society, 2016, vol. 138, # 25, p. 7820 - 7823
[5] Heterocycles, 1995, vol. 40, # 2, p. 841 - 850

2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE Suppliers

China 50 India 1 United Kingdom 2 United States 7 Global 60

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4278-08-4, 2-(4-FLUORO-PHENYL)-1H-IMIDAZOLERelated Search:

2-(2,4-DIFLUORO-PHENYL)-1H-IMIDAZOLE 2-(3,4-DIFLUORO-PHENYL)-1H-IMIDAZOLE 2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE 5-CHLORO-2-(4-FLUOROPHENYL)-BENZIMIDAZOLE 2-(4-Fluorophenyl)-5-trifluoromethyl-1H-imidazole 2-(4-fluorophenyl)-1H-benzimidazole Fenflumizole Flunidazole [2-(4-FLUORO-PHENYL)-BENZOIMIDAZOL-1-YL]-ACETIC ACID ETHYL ESTER 2-(4-FLUORO-3-TRIFLUOROMETHYL-PHENYL)-1H-IMIDAZOLE SALOR-INT L305952-1EA BUTTPARK 78\40-43 2-(4-FLUOROPHENYL)-4-TRIFLUOROMETHYL-1H-IMIDAZOLE 2-(3-CHLORO-2,4-DIFLUORO-PHENYL)-1H-IMIDAZOLE AKOS BBS-00001112 [2-(4-FLUORO-PHENYL)-1H-IMIDAZOL-4-YL]-ACETIC ACID [2-(3,4-DIFLUOROPHENYL)-IMIDAZOL-4-YL]-ACETIC ACID [2-(2,4-DIFLUOROPHENYL)-IMIDAZOL-4-YL]-ACETIC ACID

2-(4-FLUORO-PHENYL)-1H-IMIDAZOLE

2-(4-Fluorophenyl)imidazole

868764

DK7411

4278-08-4

4278/8/4