3'-Azido-3'-deoxy-2-thiouridine

Product Name: 3'-Azido-3'-deoxy-2-thiouridine
CAS No.: 2305416-00-4
Chemical Name: 3'-Azido-3'-deoxy-2-thiouridine
Synonyms: 3’-Azido-3’-deoxy-2-thiouridine;3'-Azido-3'-deoxy-2-thiouridine;1-((2R,3R,4S,5S)-4-azido-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
CBNumber: CB23334230
Molecular Formula: C9H11N5O4S
Formula Weight: 285.28
MOL File: 2305416-00-4.mol

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3'-Azido-3'-deoxy-2-thiouridine Chemical Properties,Usage,Production

Uses

3’-Azido-3’-deoxy-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-3’-deoxy-2-thiouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

3'-Azido-3'-deoxy-2-thiouridine Preparation Products And Raw materials

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2305416-00-4, 3'-Azido-3'-deoxy-2-thiouridineRelated Search:

3'-Azido-3'-deoxy-2-thiouridine

3’-Azido-3’-deoxy-2-thiouridine

1-((2R,3R,4S,5S)-4-azido-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

2305416-00-4