Ansofaxine (hydrochloride)

Product Name: Ansofaxine (hydrochloride)
CAS No.: 916918-84-8
Chemical Name: Ansofaxine (hydrochloride)
Synonyms: Y03005;LY03005;LPM570065;Ansofaxine (hydrochL;Venlafaxine EP Impurity23;Toludesvenlafaxine Hydrochloride;Ansofaxine (hydrochloride),LY03005;Ansofaxine hydrochloride, 10 mM in DMSO;LPM 570065,5-hydroxytryptamine Receptor,Dopamine Receptor,Ansofaxine hydrochloride,inhibit,Serotonin Receptor,LY-03005,LY 03005,Ansofaxine,Inhibitor,LPM-570065,5-HT Receptor
CBNumber: CB23339604
Molecular Formula: C24H32ClNO3
Formula Weight: 417.97
MOL File: 916918-84-8.mol

More

Less

Ansofaxine (hydrochloride) Property

storage temp.: Store at -20°C
solubility: DMSO : 31.25 mg/mL (74.77 mM)
form: Solid
color: White to off-white
InChI: InChI=1S/C24H31NO3.ClH/c1-18-7-9-20(10-8-18)23(26)28-21-13-11-19(12-14-21)22(17-25(2)3)24(27)15-5-4-6-16-24;/h7-14,22,27H,4-6,15-17H2,1-3H3;1H
InChIKey: BVWFJKQJRNSYCR-UHFFFAOYSA-N
SMILES: C(C1(CCCCC1)O)(C1C=CC(OC(C2C=CC(C)=CC=2)=O)=CC=1)CN(C)C.Cl

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-7132
Product name: Ansofaxinehydrochloride
Purity: 99.85%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-7132
Product name: Ansofaxinehydrochloride
Purity: 99.85%
Packaging: 10mg
Price: $340
Updated: 2021/12/16

ChemScene

Product number: CS-7132
Product name: Ansofaxinehydrochloride
Purity: 99.85%
Packaging: 20mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-7132
Product name: Ansofaxinehydrochloride
Purity: 99.85%
Packaging: 50mg
Price: $940
Updated: 2021/12/16

ChemScene

Product number: CS-7132
Product name: Ansofaxinehydrochloride
Purity: 99.85%
Packaging: 100mg
Price: $1500
Updated: 2021/12/16

More

Less

Ansofaxine (hydrochloride) Chemical Properties,Usage,Production

Uses

Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively.

in vivo

Ansofaxine rapidly penetrates the rat striatum, converts into desvenlafaxine and exhibits larger total exposure compared with the administration of desvenlafaxine. Acute and chronic administration of oral suspension of ansofaxine increases the 5-HT, dopamine and norepinephrine levels more than the relative administration of desvenlafaxine. Unlike desvenlafaxine, acute administration of an intravenous ansofaxine solution does not induce the undesirable 90% decrease in extracellular 5-HT levels. The acute administration of ansofaxine shows a capped increase in extracellular 5-HT levels when combined with WAY-100635. Acute and chronic administration of ansofaxine reduces the immobility time more than the relative administration of desvenlafaxine^[1].

IC 50

serotonin: 723 nM (IC₅₀); Dopamine Receptor: 491 nM (IC₅₀)

References

[1] Zhang R, et al. The effects of LPM570065, a novel triple reuptake inhibitor, on extracellular serotonin, dopamineand norepinephrine levels in rats. PLoS One. 2014 Mar 10;9(3):e91775. DOI:10.1371/journal.pone.0091775

Ansofaxine (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Ansofaxine (hydrochloride) Suppliers

China 31 United States 6 USA 1 Global 38

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9365
Advantage: 55

TOSUN PHARM

Tel: 61855200 13326451905
Email: 3003386889@qq.com
Country: China
ProdList: 7941
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

More

Less

View Lastest Price from Ansofaxine (hydrochloride) manufacturers

Guangzhou Tosun Pharmaceutical Ltd

Product: Toludesvenlafaxine Hydrochloride 916918-84-8
Price: US $0.00-0.00/kg
Min. Order: 5kg
Purity: 98%-102%
Supply Ability: 200kg
Release date: 2024-12-27

916918-84-8, Ansofaxine (hydrochloride)Related Search:

Ansofaxine (hydrochloride),LY03005

LPM570065

LY03005

Ansofaxine (hydrochL

Y03005

LPM 570065,5-hydroxytryptamine Receptor,Dopamine Receptor,Ansofaxine hydrochloride,inhibit,Serotonin Receptor,LY-03005,LY 03005,Ansofaxine,Inhibitor,LPM-570065,5-HT Receptor

Toludesvenlafaxine Hydrochloride

Ansofaxine hydrochloride, 10 mM in DMSO

Venlafaxine EP Impurity23

916918-84-8