GLYX13
- Product Name
- GLYX13
- CAS No.
- 1435786-04-1
- Chemical Name
- GLYX13
- Synonyms
- Rapastinel Trifluoroacetate;Rapastinel Trifluoroacetate, 10 mM in DMSO;GLYX 13,inhibit,Rapastinel Trifluoroacetate,GLYX13,GLYX-13,Inhibitor,Rapastinel,Ionotropic glutamate receptors,iGluR
- CBNumber
- CB23339886
- Molecular Formula
- C20H32F3N5O8
- Formula Weight
- 527.5
- MOL File
- 1435786-04-1.mol
GLYX13 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (236.97 mM)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- R0268
- Product name
- Rapastinel Trifluoroacetate
- Packaging
- 10MG
- Price
- $222
- Updated
- 2025/07/31
- Product number
- CS-0040824
- Product name
- Rapastinel(Trifluoroacetate)
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0040824
- Product name
- Rapastinel(Trifluoroacetate)
- Purity
- ≥98.0%
- Packaging
- 25mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- CS-0040824
- Product name
- Rapastinel(Trifluoroacetate)
- Purity
- ≥98.0%
- Packaging
- 1mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-0040824
- Product name
- Rapastinel(Trifluoroacetate)
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $210
- Updated
- 2021/12/16
GLYX13 Chemical Properties,Usage,Production
Uses
Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties. Rapastinel Trifluoroacetate has the potential for major depressive disorder treatment.
in vivo
Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties and currently in a phase II clinical development program as an adjunctive therapy for major depressive disorder. Mice given Rapastinel Trifluoroacetate (1.0 mg/kg) prior to acute ketamine (30 mg/kg) show clear preference for novel compare to familiar objects (P<0.01)[1]. Rapastinel Trifluoroacetate produces an antidepressant like effect in the USVs test, as indexed by an increase in hedonic 50-kHz USVs [F(1,20)=12.4, P<0.05] and a decrease in aversive 20-kHz USVs [F(1,20)=6.8, P<0.05]. Rapastinel Trifluoroacetate also produces an anxiolytic effect in the open field, as indexed by increased center time [F(1,20)=19.2, P<0.05] without altering locomotor activity as measured by line crosses [F(1,20)=0.0, P>0.05][2].
IC 50
NMDA Receptor
References
[1] Rajagopal L, et al. GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice. Behav Brain Res. 2016 Feb 15;299:105-10. DOI:10.1016/j.bbr.2015.10.060
[2] Burgdorf J, et al. The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience. 2015 Nov 12;308:202-11. DOI:10.1016/j.neuroscience.2015.09.004
GLYX13 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GLYX13 manufacturers
- Product
- Rapastinel Trifluoroacetate 1435786-04-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1 kg
- Release date
- 2025-06-12