GSK8814

Product Name: GSK8814
CAS No.: 1997369-78-4
Chemical Name: GSK8814
Synonyms: GSK8814;GSK8814,GSK-8814;1,7-Naphthyridin-2(1H)-one, 8-[[(3R,4R,5S)-3-[(4,4-difluorocyclohexyl)methoxy]-5-methoxy-4-piperidinyl]amino]-3-methyl-5-(5-methyl-3-pyridinyl)-
CBNumber: CB23339891
Molecular Formula: C28H35F2N5O3
Formula Weight: 527.61
MOL File: 1997369-78-4.mol

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GSK8814 Property

form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2111
Product name: GSK8814
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $183
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2111
Product name: GSK8814
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $735
Updated: 2025/07/31

ChemScene

Product number: CS-0079595
Product name: GSK8814
Packaging: 5mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0079595
Product name: GSK8814
Packaging: 10mg
Price: $510
Updated: 2021/12/16

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GSK8814 Chemical Properties,Usage,Production

Uses

GSK8814 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pKd=8.1 and a pKi=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1[1].

Biological Activity

GSK8814 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pKd=8.1 and a pKi=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1[1].

IC 50

ATAD2: 8.9 (pKi); ATAD2: 8 nM (Ki); BRD4 BD1: 4.6 (pIC₅₀)

References

[1]. Bamborough P, et al. A Chemical Probe for the ATAD2 Bromodomain. Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11382-6. [2]. Bamborough P, et al. Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors. J Med Chem. 2018 Sep 27;61(18):8321-8336.

GSK8814 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK8814 Suppliers

China 16 United States 2 Global 18

ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
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Shanghai SuperLan Chemcial Technique Centre

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Shanghai Hongye Biotechnology Co. Ltd

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Email: sales@glpbio.cn
Country: China
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TargetMol Chemicals Inc.

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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ShangHai ChuanQian Chemcial Technique Centre

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cjbscvictory

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TargetMol Chemicals Inc.

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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

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Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
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1997369-78-4, GSK8814Related Search:

GSK8814

1,7-Naphthyridin-2(1H)-one, 8-[[(3R,4R,5S)-3-[(4,4-difluorocyclohexyl)methoxy]-5-methoxy-4-piperidinyl]amino]-3-methyl-5-(5-methyl-3-pyridinyl)-

GSK8814,GSK-8814

1997369-78-4

C28H35F2N5O3