PAT-505

Product Name: PAT-505
CAS No.: 1782070-22-7
Chemical Name: PAT-505
Synonyms: PAT-505;PAT 505,PAT505;Eicosapentaenoic Acid Impurity 20;Benzoic acid, 3-[[6-chloro-2-cyclopropyl-1-(1-ethyl-1H-pyrazol-4-yl)-7-fluoro-1H-indol-3-yl]thio]-2-fluoro-
CBNumber: CB23339907
Molecular Formula: C23H18ClF2N3O2S
Formula Weight: 473.92
MOL File: 1782070-22-7.mol

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PAT-505 Property

Boiling point:: 550.0±50.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 48.33 mg/mL (101.98 mM)
form: Solid
pka: 2.98±0.10(Predicted)
color: Pale purple to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0030523
Product name: PAT-505
Purity: 99.47%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0030523
Product name: PAT-505
Purity: 99.47%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0030523
Product name: PAT-505
Purity: 99.47%
Packaging: 50mg
Price: $2850
Updated: 2021/12/16

ChemScene

Product number: CS-0030523
Product name: PAT-505
Purity: 99.47%
Packaging: 100mg
Price: $3950
Updated: 2021/12/16

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PAT-505 Chemical Properties,Usage,Production

Uses

PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma.

in vivo

PAT-505 suppresses ATX lysoPLD activity with an average IC₅₀ value of 62 nM and an average IC₉₀ value of 630 nM in mouse plasma, and the IC₉₀ in rat plasma is ～770 nM. PAT-505 (30 mg/kg, p.o.) significantly reduces fibrotic score, the percentage of PSR-positive area, and α-SMA immunoreactivity in mouse model of nonalcoholic steatohepatitis (NASH)^[1].

IC 50

Autotaxin: 2 nM (IC₅₀, In Hep3B cells); Autotaxin: 9.7 nM (IC₅₀, In human blood ); Autotaxin: 62 nM (IC₅₀, In mouse plasma)

References

[1] Bain G, et al. Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13. Epub 2016 Oct 17. DOI:10.1124/jpet.116.237156

PAT-505 Preparation Products And Raw materials

Raw materials

Preparation Products

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PAT-505 Suppliers

China 14 United States 3 Global 17

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Shanghai hongqu biomedical technology co. LTD

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Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

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Guangzhou Yunmen Biotechnology Co., Ltd

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Kaifeng Mingren Pharmaceutical Co.,LTD

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TargetMol Chemicals Inc.

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Email: marketing@tsbiochem.com
Country: China
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Qiyuan (Guangdong) Pharmaceutical Chemical Co., Ltd.

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Shanghai Yifei Biotechnology Co. , Ltd.

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guoyungurui

Tel: 18162595016; 18162595016
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1782070-22-7, PAT-505Related Search:

PAT-505

Benzoic acid, 3-[[6-chloro-2-cyclopropyl-1-(1-ethyl-1H-pyrazol-4-yl)-7-fluoro-1H-indol-3-yl]thio]-2-fluoro-

PAT 505,PAT505

Eicosapentaenoic Acid Impurity 20

1782070-22-7