AN-7
- Product Name
- AN-7
- CAS No.
- 213262-83-0
- Chemical Name
- AN-7
- Synonyms
- Butanoic acid, [(diethoxyphosphinyl)oxy]methyl ester
- CBNumber
- CB23358865
- Molecular Formula
- C9H19O6P
- Formula Weight
- 254.22
- MOL File
- 213262-83-0.mol
AN-7 Chemical Properties,Usage,Production
Description
AN-7 is a potent HDAC inhibitor, is also a prodrug of butyric acid, which induced histone hyperacetylation and differentiation and inhibited proliferation of human prostate 22Rv1 cancer cells in vitro and in vivo. AN-7 is likely to display a high therapeutic index and may be beneficial for prostate cancer patients.
Uses
AN-7 is an orally active histone deacetylase (HDAC) inhibitor that induces histone hyperacetylation and differentiation in vitro and in vivo, and inhibits the proliferation of human prostate 22Rv1 cancer cells. AN-7 can increase the expression of the pro-apoptotic protein Bax, reduce the expression of the anti-apoptotic protein Bcl-2, and promote apoptosis by activating caspase-3, and can be used in the study of prostate cancer[1].
References
[1] Rephaeli, et al. In vivo and in vitro antitumor activity of butyroyloxymethyl‐diethyl phosphate (AN‐7), a histone deacetylase inhibitor, in human prostate cancer. International journal of cancer 116.2 (2005): 226-235. DOI:10.1002/ijc.21030