6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid

Appearance

Product Name: 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
CAS No.: 397864-40-3
Chemical Name: 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
Synonyms: GW675713X;BNKY012-FF04;Fluticasone furoate impurity 03;Fluticasone Carbothioic Acid Fuorate;6α,9-Difluoro-11-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17-yl-2-furancarboxylate carbothioic S-acid;6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid;6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-（1-1-furancarboxylic）-1,4-diene-17β-thiocarboxylic acid;Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxo-, (6α,11β,16α,17α)-;(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid (>85%);Fluticasone Impurity(6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-（1-1-furancarboxylic）-1,4-diene-17β-thiocarboxylic acid)
CBNumber: CB23372041
Molecular Formula: C26H28F2O6S
Formula Weight: 506.56
MOL File: 397864-40-3.mol

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6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid Property

Melting point:: >154°C (dec.)
Boiling point:: 622.1±55.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Chlroform (Slightly, Heated, Sonicated)
pka: 2.97±0.70(Predicted)
form: Solid
color: White to Off-White
Stability:: Air Sensitive
InChIKey: CDZNLVUCJXQAPI-FFHMMLLQNA-N
SMILES: C[C@]12C[C@H](O)[C@@]3([C@]4(C=CC(=O)C=C4[C@@H](F)C[C@@]3([H])[C@]1([H])C[C@@H](C)[C@@]2(C(S)=O)OC(C1OC=CC=1)=O)C)F |&1:1,3,5,6,13,16,18,21,23,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P314Get medical advice/attention if you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D450256
Product name: (6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioicAcid(>85%)
Packaging: 10mg
Price: $185
Updated: 2021/12/16

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6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid Chemical Properties,Usage,Production

Appearance

White to Off-White Solid

Uses

(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid is a steroid used in the preparation of crystalline forms of the therapeutically useful anti-inflammatory corticosteroid fluticasone furoate (I) and its solvates. A fluticasone furoate (F599510) impurity.

Synthesis

A suspension of 17β-[(N, N-dimethylcarbamoyl)thio]carbonyl-6α,9α-difluoro-17α-[(2-furanylcarbonyl)oxy]-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene (14.2 g, 0.024 mol) and potassium carbonate (6.78 g, 0.0491 mol) in methanol (70 ml) was stirred at ambient temperature for 6 hrs under a blanket of nitrogen. After that, water was added to the reaction mixture, and the clear solution was washed with toluene. The aqueous layer containing the product was charcoalized and then acidified with 2N HCl until pH was 1.5 to 2.0. The precipitated product was filtered, washed with water, and dried to yield 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid as a white solid (11.8 g, 94.8%).

6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid Suppliers

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View Lastest Price from 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid manufacturers

Moxin Chemicals

Product: Fluticasone Furoate Impurity 397864-40-3
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 100000
Release date: 2025-03-12

Zibo Hangyu Biotechnology Development Co., Ltd

Product: GW675713X 397864-40-3
Price: US $75.00-750.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-06

397864-40-3, 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acidRelated Search:

Fluticasone Impurity FLUTICASONE PROPIONATE INTERMEDIATE Fluticasone (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)thio]nonyl]-estra-1,3,5(10)-triene-3,17-diol FLUTICASONE FUROATE FLWQKNXBDAHGQO-PIKHTVJPSA-N Fluticasone Impurity

6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid

BNKY012-FF04

GW675713X

Fluticasone Carbothioic Acid Fuorate

Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxo-, (6α,11β,16α,17α)-

(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-((furan-2-carbonyl)oxy)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid

(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid (>85%)

Fluticasone Thioacid-17-furoateQ: What is Fluticasone Thioacid-17-furoate Q: What is the CAS Number of Fluticasone Thioacid-17-furoate

6α,9-Difluoro-11-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17-yl-2-furancarboxylate carbothioic S-acid

Fluticasone furoate impurity 03

6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-（1-1-furancarboxylic）-1,4-diene-17β-thiocarboxylic acid

Fluticasone Impurity(6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-（1-1-furancarboxylic）-1,4-diene-17β-thiocarboxylic acid)

(6Alpha,11Beta,16Alpha,17Alpha)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid (>85%)

397864-40-3

C26H28F2O6S