5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene

Product Name: 5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene
CAS No.: 239066-73-0
Chemical Name: 5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene
Synonyms: AL438;AL 438;AL-438;5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline;1H-[1]Benzopyrano[3,4-f]quinoline, 2,5-dihydro-10-methoxy-2,2,4-trimethyl-5-(2-propen-1-yl)-;5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene
CBNumber: CB23372278
Molecular Formula: C23H25NO2
Formula Weight: 347.45
MOL File: 239066-73-0.mol

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5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene Chemical Properties,Usage,Production

Description

AL-438 is a non-steroidal selective modulator for the glucocorticoid receptor (GR).

Uses

AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2].

in vivo

AL-438 (1, 10, 100 mg/kg; p.o.) shows anti-inflammatory activity in rats^[2].

Animal Model:	Male Sprague Dawley rats (carrageenan paw edema model)^[2]
Dosage:	1, 10, 100 mg/kg
Administration:	P.o.
Result:	Showed antiinflammatory activity with ED₅₀ value of 11 mg/kg in acute inflammation assay.

References

[1] Owen HC, et al. The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70. DOI:10.1016/j.mce.2006.11.006
[2] Coghlan MJ, et al. A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects. Mol Endocrinol. 2003 May;17(5):860-9. DOI:10.1210/me.2002-0355

5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene Preparation Products And Raw materials

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5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene Suppliers

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239066-73-0, 5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chryseneRelated Search:

5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene

1H-[1]Benzopyrano[3,4-f]quinoline, 2,5-dihydro-10-methoxy-2,2,4-trimethyl-5-(2-propen-1-yl)-

AL 438

AL438

AL-438

5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline

239066-73-0