(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide

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(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide

Product Name: (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide
CAS No.: 1417997-93-3
Chemical Name: (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide
Synonyms: 22d;HDAC8-IN-1;CS-2693;MDK-7933;INVIVO-7933;HDAC8-IN-22d;HDAC8-IN-1(22d);HDAC8 inhibitor 1;HDAC8 inhibitor 22d;HDAC8-IN-1 ,MDK7933
CBNumber: CB23373154
Molecular Formula: C22H19NO3
Formula Weight: 345.39
MOL File: 1417997-93-3.mol

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(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Property

Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A solid
pka: 8.76±0.23(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28832
Product name: HDAC8-IN-1
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 28832
Product name: HDAC8-IN-1
Packaging: 25mg
Price: $692
Updated: 2024/03/01

Cayman Chemical

Product number: 28832
Product name: HDAC8-IN-1
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 28832
Product name: HDAC8-IN-1
Packaging: 10mg
Price: $321
Updated: 2024/03/01

TRC

Product number: H805220
Product name: (2E)-N-Hydroxy-3-(5-methoxy[1,1'':4'',1''''-terphenyl]-2-yl)-2-propenamide
Packaging: 5mg
Price: $275
Updated: 2021/12/16

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(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Chemical Properties,Usage,Production

Description

HDAC8-IN-1 is an inhibitor of histone deacetylase 8 (HDAC8; IC₅₀ = 27.2 nM). It is selective for HDAC8 over HDAC1-3, -4, -6, -10, and -11 (IC₅₀s = ≥3,000 nM for all). HDAC8-IN-1 is cytotoxic to A549, H1299, and CL1-5 lung cancer cells (IC₅₀s = 7.9, 7.2, and 7 μM, respectively).

Uses

(2E)-N-Hydroxy-3-(5-methoxy[1,1'':4'',1''''-terphenyl]-2-yl)-2-propenamide, is a HDAC8 inhibitor with an IC50 of 27.2 nM.

(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide Preparation Products And Raw materials

Raw materials

Preparation Products

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1417997-93-3, (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamideRelated Search:

3-Piperidinecarboxamide, N-methyl-N-(phenylmethyl)-1-[[4-(trifluoromethyl)phenyl]methyl]-, hydrochloride (1:1) N-benzyl-N-Methyl-1-(4-(trifluoroMethyl)benzyl)piperidine-3-carboxaMide

(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide

HDAC8-IN-1

HDAC8-IN-1 ,MDK7933

MDK-7933

HDAC8 inhibitor 1

CS-2693

HDAC8 inhibitor 22d

HDAC8-IN-22d

2-Propenamide, N-hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-, (2E)-

(2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide

(E)-N-Hydroxy-3-(5-methoxy-[1,1':4',1''-terphenyl]-2-yl)acrylamide

INVIVO-7933

22d

HDAC-8-IN-1,HDAC8IN1,Histone deacetylases,Inhibitor,inhibit,HDAC,HDAC8 IN 1

HDAC8-IN-1(22d)

(E)-N-Hydroxy-3-(5-methoxy-[1,1':4',1''-terphenyl]-2-yl)acrylamide

(2E)-3-(2-{[1,1'-biphenyl]-4-yl}-4-methoxyphenyl)-N-hydroxyprop-2-enamide

1417997-93-3

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