MELK-T1(JNJ-47117096) HCl
- Product Name
- MELK-T1(JNJ-47117096) HCl
- CAS No.
- 1610536-69-0
- Chemical Name
- MELK-T1(JNJ-47117096) HCl
- Synonyms
- MELK-T1 HCl;MELK-T1 HCl salt;JNJ-47117096 hcl;MELK-T1 HYDROCHLORIDE;MELK-T1(JNJ-47117096) HCl;JNJ-47117096 hydrochloride;JNJ 47117096 hydrochloride,JNJ47117096 hydrochloride
- CBNumber
- CB23374494
- Molecular Formula
- C21H23ClN4O2
- Formula Weight
- 398.89
- MOL File
- 1610536-69-0.mol
MELK-T1(JNJ-47117096) HCl Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 250 mg/mL (626.74 mM)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0011272
- Product name
- JNJ-47117096hydrochloride
- Purity
- 99.40%
- Packaging
- 5mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- CS-0011272
- Product name
- JNJ-47117096hydrochloride
- Purity
- 99.40%
- Packaging
- 10mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CS-0011272
- Product name
- JNJ-47117096hydrochloride
- Purity
- 99.40%
- Packaging
- 25mg
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- CS-0011272
- Product name
- JNJ-47117096hydrochloride
- Purity
- 99.40%
- Packaging
- 50mg
- Price
- $1700
- Updated
- 2021/12/16
- Product number
- CS-0011272
- Product name
- JNJ-47117096hydrochloride
- Purity
- 99.40%
- Packaging
- 100mg
- Price
- $2700
- Updated
- 2021/12/16
MELK-T1(JNJ-47117096) HCl Chemical Properties,Usage,Production
Biological Activity
MELK-T1(JNJ-47117096) HCl is a potent and selective MELK inhibitor with IC50 value of 23 nM; it also has strong effect on Flt3 with IC50 value of 18 nM.
in vitro
MELK-T1(JNJ-47117096) HCl is potent and selective MELK inhibitor, with an IC 50 of 23 nM, also effectively inhibits Flt3, with an IC 50 of 18 nM, and slighitly blocks CAMKIIδ, Mnk2, CAMKIIγ, and MLCK (IC 50 , 810 nM, 760 nM, 1000 nM, 1000 nM). It suppresses the proliferation of Flt3 -driven Ba/F3 cell lines, with an IC 50 of 1.5 μM in the absence of IL-3, while no inhibitory activity is observed in the presence of IL-3. It does not inhibit the proliferation of Ba/F3 cell lines transfected with either FGFR1, FGFR3, or KDR, either in the presence or absence of IL-3. JNJ-47117096 (MELK-T1, 10 μM) delays the progression of MCF-7 cells through S -phase. JNJ-47117096 inhibits MELK, and then exerts stalled replication forks and DNA double-strand breaks (DSBs). JNJ-47117096 activates the ATM-mediated DNA-damage response (DDR). JNJ-47117096 (3, 10 μM) results in a growth arrest and a senescent phenotype. Moreover, JNJ-47117096 induces a strong phosphorylation of p53, a prolonged up-regulation of p21 and a down-regulation of FOXM1 target genes.
target
IC50: 23 nM (MELK), 18 nM (Flt3)
MELK-T1(JNJ-47117096) HCl Preparation Products And Raw materials
Raw materials
Preparation Products
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