ChemicalBook > CAS DataBase List > Selective PI3Kδ Inhibitor 1
Selective PI3Kδ Inhibitor 1
- Product Name
- Selective PI3Kδ Inhibitor 1
- CAS No.
- 2088525-31-7
- Chemical Name
- Selective PI3Kδ Inhibitor 1
- Synonyms
- PI3Kδ-IN-5;compound 7n;PI3Kδ-IN-7n;PI3K delta-IN-7n;SelectivePI3KδInhibitor1;Selective PI3Kδ Inhibitor 1;SelectivePI3KδInhibitor1(compound7n);SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N;4-(3-Amino-6-(1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl)pyrazin-2-yl)-2-fluorobenzamide;Benzamide, 4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl]-2-pyrazinyl]-2-fluoro-
- CBNumber
- CB23379666
- Molecular Formula
- C23H20FN7O
- Formula Weight
- 429.45
- MOL File
- 2088525-31-7.mol
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Selective PI3Kδ Inhibitor 1 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 43 mg/mL (100.13 mM);Ethanol: Insoluble
- form
- Solid
- color
- Off-white to gray
- Water Solubility
- Water: Insoluble
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Selective PI3Kδ Inhibitor 1 Chemical Properties,Usage,Production
Biological Activity
Selective PI3Kδ Inhibitor 1 (compound 7n) is a PI3Kδ inhibitor with IC50 of 0.9 nM for PI3Kδ, which is more than 1000-fold selective for other class I PI3K isoforms. The IC50 values of it for PI3Kα/γ/β were 3670, 1460, and 21300 nM, respectively.
in vivo
Selective PI3Kδ Inhibitor 1 has favorable pharmacokinetic profile: good bioavailability and moderate in vivo half-life. In rats, its oral bioavailability was 41%; after intravenous injection, Vss, T 1/2 and CL were 2.8 L/kg, 3.4 h and 12 mL/min/kg, respectively .
target
| Target | Value |
| PI3Kδ (Cell-free assay) | 0.9 nM |
Selective PI3Kδ Inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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