ChemicalBook > CAS DataBase List > LXH254,LXH-254

LXH254,LXH-254

Product Name: LXH254,LXH-254
CAS No.: 1800398-38-2
Chemical Name: LXH254,LXH-254
Synonyms: LXH254;Naporafenib;LXH254,LXH-254;LXH254 (NAPORAFENIB);LXH254, 10 mM in DMSO;Naporafenib (LXH-254);LXH254; LXH-254; LXH 254;N-[3-[2-(2-Hydroxyethoxy)-6-morpholino-4-pyridyl]-4-methylphenyl]-2-(trifluoromethyl)isonicotinamide;N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide;N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide?, LXH254
CBNumber: CB23380035
Molecular Formula: C25H25F3N4O4
Formula Weight: 502.49
MOL File: 1800398-38-2.mol

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LXH254,LXH-254 Property

Boiling point:: 601.9±55.0 °C(Predicted)
Density: 1.353±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);199.0(Max Conc. mM)
form: A crystalline solid
pka: 10.86±0.70(Predicted)
color: Off-white to light yellow
InChIKey: UEPXBTCUIIGYCY-UHFFFAOYSA-N
SMILES: C1(C(F)(F)F)=NC=CC(C(NC2=CC=C(C)C(C3C=C(N4CCOCC4)N=C(OCCO)C=3)=C2)=O)=C1

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28231
Product name: LXH254
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 28231
Product name: LXH254
Packaging: 25mg
Price: $819
Updated: 2024/03/01

Cayman Chemical

Product number: 28231
Product name: LXH254
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 28231
Product name: LXH254
Packaging: 10mg
Price: $477
Updated: 2024/03/01

TRC

Product number: L395010
Product name: LXH254
Packaging: 25mg
Price: $1945
Updated: 2021/12/16

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LXH254,LXH-254 Chemical Properties,Usage,Production

Uses

LXH254, is a kinase inhibitor used in the treatment of solid tumors.

in vivo

Treatment with Naporafenib (Compound A) generates tumor regression in several KRAS-mutant models including the NSCLC-derived Calu-6 (KRAS Q61K) and NCI-H358 (KRAS G12C). Naporafenib exhibits efficacy in numerous MAPK-driven human cancer cell lines and in xenograft tumors representing model tumors harboring human lesions in KRAS, NRAS and BRAF oncogenes^[1].
Naporafenib shows significant antitumor activity in models harboring BRAF mutations either alone or coincident with either activated NRAS or KRAS, and RAS mutants lacking ARAF are more sensitive to Naporafenib^[2].

Animal Model:	Outbred athymic (nu/nu) female mice and SCID Beige mice; BRAF-, NRAS-, and KRAS-mutant xenograft models, as well as a RAS/RAF wild-type model^[2]
Dosage:	100 mg/kg
Administration:	Orally, daily
Result:	Significantly decreased tumor volume in models harboring BRAF mutations either alone or coincident with either activated NRAS or KRAS, slightly decreased tumor volume in KRAS model.

IC 50

CRAF: 0.072 nM (IC₅₀); Braf: 0.21 nM (IC₅₀); ARAF: 6.4 nM (IC₅₀); p38α: 2.1 μM (IC₅₀); Abl1: 4.9 μM (IC₅₀)

LXH254,LXH-254 Preparation Products And Raw materials

Raw materials

Preparation Products

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LXH254,LXH-254 Suppliers

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1800398-38-2, LXH254,LXH-254Related Search:

LXH254; LXH-254; LXH 254

LXH254,LXH-254

LXH254

4-Pyridinecarboxamide, N-[3-[2-(2-hydroxyethoxy)-6-(4-morpholinyl)-4-pyridinyl]-4-methylphenyl]-2-(trifluoromethyl)-

Naporafenib

Bcr-Abl,A375,Inhibitor,p38 MAPK,LXH 254,inhibit,Raf,Mia PaCa-2,Raf kinases,HCT116,LXH254,Selective,MEL-JUSO,LXH-254

N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide

Naporafenib (LXH-254)

N-[3-[2-(2-Hydroxyethoxy)-6-morpholino-4-pyridyl]-4-methylphenyl]-2-(trifluoromethyl)isonicotinamide

LXH254 (NAPORAFENIB)

LXH254, 10 mM in DMSO

N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide?, LXH254

1800398-38-2

C25H25F3N4O4