E3 ligase Ligand 5
- Product Name
- E3 ligase Ligand 5
- CAS No.
- 1264754-13-3
- Chemical Name
- E3 ligase Ligand 5
- Synonyms
- E3 ligase Ligand 5;PROTAC ERRα ligand 1;PROTAC ERRa ligand 1;PROTAC ERRα ligand 1, 10 mM in DMSO;(Z)-4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile;PROTAC ERRα ligand 1,inhibit,PROTAC ERRα ligand-1,Inhibitor,PROTAC ERRα ligand1,Estrogen Receptor/ERR;Benzonitrile, 4-[4-[(Z)-(2,4-dioxo-5-thiazolidinylidene)methyl]-2-methoxyphenoxy]-3-(trifluoromethyl)-;4-[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxyphenoxy]-3-(trifluoromethyl)benzonitrile
- CBNumber
- CB23384770
- Molecular Formula
- C19H11F3N2O4S
- Formula Weight
- 420.36
- MOL File
- 1264754-13-3.mol
E3 ligase Ligand 5 Property
- Density
- 1.53±0.1 g/cm3(Predicted)
- pka
- 7.31±0.20(Predicted)
- form
- Solid
- color
- Light yellow to green yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
E3 ligase Ligand 5 Chemical Properties,Usage,Production
Description
E3L-4133, also known as E3 ligase Ligand 5, is an E3 ligase Ligand that can be used in PROTAC (proteolysis targeting chimera) technology to engage an E3 ubiquitin ligase. PROTAC is a two-headed molecule capable of removing specific unwanted proteins.
Uses
PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist with IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively[1].
target
PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist.
IC 50
ERRα: 0.04 μM (IC50); ERRγ: 2.8 μM (IC50)
References
[1] Patch RJ, et al. Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents. J Med Chem. 2011 Feb 10;54(3):788-808. DOI:10.1021/jm101063h
E3 ligase Ligand 5 Preparation Products And Raw materials
Raw materials
Preparation Products
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