SB-568849

Product Name: SB-568849
CAS No.: 395679-53-5
Chemical Name: SB-568849
Synonyms: SB-568849;SB 568849,SB568849;[1,1'-Biphenyl]-4-carboxamide, N-[4-[2-(diethylamino)ethoxy]-3-methoxyphenyl]-N-methyl-4'-(trifluoromethyl)-
CBNumber: CB23384785
Molecular Formula: C28H31F3N2O3
Formula Weight: 500.55
MOL File: 395679-53-5.mol

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SB-568849 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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SB-568849 Chemical Properties,Usage,Production

Uses

SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pKi of 7.7.

in vivo

SB-568849 (Compound 15h) possesses good receptor affinity and selectivity. SB-568849 proves to be an antagonist with stability in vivo, an acceptable brain–blood ratio and oral bioavailability. SB-568849 retains affinity, demonstrates greater in vivo stability (CL_b=16 mL/min/kg) and shows an acceptable brain-blood ratio of 1. SB-568849 also shows >30-fold selectivity over a wide range of monoamine receptors and is an antagonist in the FLIPR assay with a pK_b of 7.7^[3].

References

[1] Witty DR, et al. Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4872-8. DOI:10.1016/j.bmcl.2006.06.061
[2] Kennedy AR, et al. Effect of direct injection of melanin-concentrating hormone into the paraventricular nucleus: further evidence for a stimulatory role in the adrenal axis via SLC-1. J Neuroendocrinol. 2003 Mar;15(3):268-72. DOI:10.1046/j.1365-2826.2003.00997.x
[3] Witty DR, et al. SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4865-71. DOI:10.1016/j.bmcl.2006.06.056

SB-568849 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB-568849 Suppliers

China 7 United States 3 Global 10

Twochem Co.Ltd.

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TargetMol Chemicals Inc.

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Beijing Jin Ming Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Jinan Dingguo Biotechnology Co., Ltd.

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395679-53-5, SB-568849Related Search:

SB-568849

[1,1'-Biphenyl]-4-carboxamide, N-[4-[2-(diethylamino)ethoxy]-3-methoxyphenyl]-N-methyl-4'-(trifluoromethyl)-

SB 568849,SB568849

395679-53-5