ChemicalBook > CAS DataBase List > N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide

Product Name: N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
CAS No.: 1052147-86-0
Chemical Name: N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
Synonyms: LP21;LP-211;LP-211 >=98% (HPLC);LP-211, 10 mM in DMSO;LP-211; LP 211; LP211;1052147-86-0;N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide;1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-;LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit
CBNumber: CB23385434
Molecular Formula: C30H34N4O
Formula Weight: 466.62
MOL File: 1052147-86-0.mol

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N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Property

Boiling point:: 714.8±60.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:100.0(Max Conc. mg/mL);214.3(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);107.15(Max Conc. mM)
pka: 15.39±0.46(Predicted)
form: solid
color: clear white to light brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1561
Product name: LP-211
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $96.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1561
Product name: LP-211
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $390.6
Updated: 2025/07/31

Cayman Chemical

Product number: 29659
Product name: LP-211
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29659
Product name: LP-211
Packaging: 25mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 29659
Product name: LP-211
Purity: ≥98%
Packaging: 50mg
Price: $243
Updated: 2024/03/01

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N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Chemical Properties,Usage,Production

Uses

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor used in pharmacological studies which showed that it underwent metabolic breakdown to RA-7 and showed pharmacological activities such as induced hypothermia in mice and showed optimal pharmacokinetics in rats.LP-211 is also a drug analogue of piperazinehexanamide exhibiting 5-HT7 receptor affinity.

Biochem/physiol Actions

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.

in vivo

LP-211 (10 mg/kg, i.p.) rapidly reaches the systemic circulation in the mouse, with mean C_max of 0.76 ± 0.32 μg/mL at 30 min^[1]. LP-211 (0.003-0.3 mg/kg, i.p.) significantly increases the micturition volume in a dose-dependent manner, and causes significant increases in voiding efficiency in spinal cord-injured (SCI) rats, and such effects can be completely reversed by SB-269970^[2]. LP-211 (0.25 and 0.50 mg/kg i.p.) improves consolidation of chamber-shape memory in rats, resulting in significant novelty-induced hyperactivity and recognition^[3].

IC 50

5-HT₇ Receptor: 0.58 nM (Ki); 5-HT_1A Receptor: 188 nM (Ki); D₂ Receptor: 142 nM (Ki)

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Suppliers

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1052147-86-0, N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamideRelated Search:

LP-211

N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide

LP-211; LP 211; LP211;1052147-86-0

LP21

LP-211 >=98% (HPLC)

LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit

1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-

LP-211, 10 mM in DMSO

1052147-86-0

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