E3 ligase Ligand-Linker Conjugates 3

Product Name: E3 ligase Ligand-Linker Conjugates 3
CAS No.: 2101200-09-1
Chemical Name: E3 ligase Ligand-Linker Conjugates 3
Synonyms: VH032-PEG1-N3;(S,R,S)-AHPC-PEG1-azide;VHL Ligand-Linker Conjugates 9;(S,R,S)-AHPC-PEG1-N3, 10 mM in DMSO;E3 ligase Ligand-Linker Conjugates 3;E3 Ligase Ligand-Linker Conjugates,(S,R,S) AHPC PEG1 N3,Inhibitor,(S,R,S)-AHPC-PEG-1-N3,(S,R,S)AHPCPEG1N3,inhibit;L-Prolinamide, N-[2-(2-azidoethoxy)acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(2-(2-azidoethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CBNumber: CB23386471
Molecular Formula: C26H35N7O5S
Formula Weight: 557.67
MOL File: 2101200-09-1.mol

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E3 ligase Ligand-Linker Conjugates 3 Property

storage temp.: 2-8°C
form: Solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 903957
Product name: (S,R,S)-AHPC-PEG1-azide
Packaging: 50mg
Price: $517
Updated: 2024/03/01

Iris Biotech GmbH

Product number: PTC1590
Product name: (S,R,S)-AHPC-PEG1-N3
Packaging: 50mg
Price: $634.5
Updated: 2021/12/16

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E3 ligase Ligand-Linker Conjugates 3 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG1-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reaction type: click chemistry
reagent type: ligand-linker conjugate

E3 ligase Ligand-Linker Conjugates 3 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand-Linker Conjugates 3 Suppliers

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View Lastest Price from E3 ligase Ligand-Linker Conjugates 3 manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (S,R,S)-AHPC-PEG1-azide 2101200-09-1
Price: US $0.00/mg
Min. Order: 100mg
Purity: >98.00%
Supply Ability: 100mg
Release date: 2024-04-01

2101200-09-1, E3 ligase Ligand-Linker Conjugates 3Related Search:

E3 ligase Ligand-Linker Conjugates 3

(S,R,S)-AHPC-PEG1-azide

VH032-PEG1-N3

VHL Ligand-Linker Conjugates 9

E3 Ligase Ligand-Linker Conjugates,(S,R,S) AHPC PEG1 N3,Inhibitor,(S,R,S)-AHPC-PEG-1-N3,(S,R,S)AHPCPEG1N3,inhibit

(2S,4R)-1-((S)-2-(2-(2-azidoethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

L-Prolinamide, N-[2-(2-azidoethoxy)acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

(S,R,S)-AHPC-PEG1-N3, 10 mM in DMSO

2101200-09-1