Phen-DC3 Trifluoromethanesulfonate
- Product Name
- Phen-DC3 Trifluoromethanesulfonate
- CAS No.
- 929895-45-4
- Chemical Name
- Phen-DC3 Trifluoromethanesulfonate
- Synonyms
- Phen-DC3 Triflate;Phen-DC3 Trifluoromethanesulfonate
- CBNumber
- CB23386507
- Molecular Formula
- C36H26F6N6O8S2
- Formula Weight
- 848.7474592
- MOL File
- 929895-45-4.mol
Phen-DC3 Trifluoromethanesulfonate Property
- Melting point:
- >260 °C(Solv: ethyl ether (60-29-7))
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 34 mg/mL (40.06 mM)
- form
- Solid
- color
- White to light yellow
N-Bromosuccinimide Price
- Product number
- CS-7711
- Product name
- Phen-DC3Trifluoromethanesulfonate
- Purity
- 99.53%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-7711
- Product name
- Phen-DC3Trifluoromethanesulfonate
- Purity
- 99.53%
- Packaging
- 5mg
- Price
- $540
- Updated
- 2021/12/16
- Product number
- CS-7711
- Product name
- Phen-DC3Trifluoromethanesulfonate
- Purity
- 99.53%
- Packaging
- 10mg
- Price
- $900
- Updated
- 2021/12/16
- Product number
- CS-7711
- Product name
- Phen-DC3Trifluoromethanesulfonate
- Purity
- 99.53%
- Packaging
- 50mg
- Price
- $2700
- Updated
- 2021/12/16
Phen-DC3 Trifluoromethanesulfonate Chemical Properties,Usage,Production
Biological Activity
Phen-DC3 Trifluoromethanesulfonate is a G4-specific ligand that inhibits the helicases FANCJ and DinG with IC50s of 65±6 and 50±10 nM, respectively.
in vitro
In WT cells, a CEB1-WT array is rather stable but undergoes frequent rearrangements upon addition of 10 μM Phen-DC3 Trifluoromethanesulfonate (Phen-DC3). It is found that the c-Myc allele exhibits significant destabilization upon Phen-DC3 Trifluoromethanesulfonate treatment and PIF1 deletion. The CEB25-L111(T) array is stable in WT cells, it becomes unstable upon addition of Phen-DC3 Trifluoromethanesulfonate or deletion of PIF1. It is also highly destabilized in the presence of Phen-DC3 Trifluoromethanesulfonate or in the absence of PIF1. The CEB1-loop CEB25 allele remains fully stable in both PIF1-treated and WT cells.
target
IC50: 65±6 nM (G4 substrate, FANCJ helicase), 50±10 nM (G4 substrate, DinG helicases)
Phen-DC3 Trifluoromethanesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
Phen-DC3 Trifluoromethanesulfonate Suppliers
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