sodium 8-amino-5-chloro-1-oxo-7-phenyl-2H-pyrido[3,4-d]pyridazin-4-olate
- Product Name
- sodium 8-amino-5-chloro-1-oxo-7-phenyl-2H-pyrido[3,4-d]pyridazin-4-olate
- CAS No.
- 143556-24-5
- Chemical Name
- sodium 8-amino-5-chloro-1-oxo-7-phenyl-2H-pyrido[3,4-d]pyridazin-4-olate
- Synonyms
- L 012 sodium salt;L 012 sodium salt, 10 mM in DMSO;1H-Benz[e]indole-6,8-disulfonic acid, 1,1,2-trimethyl-;sodium 8-amino-5-chloro-1-oxo-7-phenyl-2H-pyrido[3,4-d]pyridazin-4-olate;8-Amino-5-chloro-2,3-dihydro-7-phenyl-pyrido[3,4-d]pyridazine sodium salt;8-Amino-5-chloro-7-phenyl-2,3-dihydropyrido[3,4-d]pyridazine-1,4-dione sodium salt
- CBNumber
- CB23414213
- Molecular Formula
- C13H8ClN4NaO2
- Formula Weight
- 310.67099
- MOL File
- 143556-24-5.mol
sodium 8-amino-5-chloro-1-oxo-7-phenyl-2H-pyrido[3,4-d]pyridazin-4-olate Property
- storage temp.
- -20°C
- solubility
- Soluble to 20 mM in water and to 100 mM in DMSO
- form
- Solid
- color
- White to yellow
- Water Solubility
- H2O: 2mg/mL, clear
- InChI
- InChI=1S/C13H9ClN4O2.Na/c14-11-8-7(12(19)17-18-13(8)20)9(15)10(16-11)6-4-2-1-3-5-6;/h1-5H,15H2,(H,17,19)(H,18,20);/q;+1/p-1
- InChIKey
- IGEUYSJHQQCEFP-UHFFFAOYSA-M
- SMILES
- [Na+].C1([O-])=NNC(=O)C2=C(N)C(C3=CC=CC=C3)=NC(Cl)=C12
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- SML2236
- Product name
- L-012 sodium salt
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $134
- Updated
- 2025/07/31
- Product number
- SML2236
- Product name
- L-012 sodium salt
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $511.1
- Updated
- 2025/07/31
- Product number
- 5085
- Product name
- L-012 sodium salt
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $278
- Updated
- 2021/12/16
- Product number
- L473478
- Product name
- L-012 sodium salt
- Packaging
- 10mg
- Price
- $255
- Updated
- 2021/12/16
- Product number
- 255621
- Product name
- L 012 sodium salt
- Packaging
- 10mg
- Price
- $579
- Updated
- 2021/12/16
sodium 8-amino-5-chloro-1-oxo-7-phenyl-2H-pyrido[3,4-d]pyridazin-4-olate Chemical Properties,Usage,Production
Description
L 012 sodium salt is a luminal-based chemiluminescent dye and probe. It is used to detect superoxide in biological systems, specifically in whole inflammatory cells, vascular tissue and blood. It could detect NAPDH oxidase-derived reactive oxygen and nitrogen species (ROS and RNS). It is active in vitro and in vivo.
Uses
L 012 Sodium Salt is a chemiluminescent dye used to detect superoxide in biological systems, specifically in whole blood, inflammatory cells, and vascular tissue.
Biological Activity
L-012 is a luminol analog and a widely used reactive oxygen and nitrogen species (RONS; ROS & RNS) chemiluminescence (CL) probe both in cultures and in animals in vivo. L-012 displays significantly higher CL yield and sensitivity than luminol, lucigenin and MCLA. Instead of reacting with superoxide anion (O2-) directly, L-012 (LumH2) is converted via a one-electron oxidation (catalyzed by peroxidase in the presence of H2O2) to the LumH· radical form, which then reacts with oxygen (O2) to yield O2- and L-012 quinone (q-Lum). The O2- in turn reacts with the LumH· radical, leading eventually to an endoperoxide th at decomposes to emit luminescence. To a less extend, H2O2 can also react with q-Lum to yield luminescence. Although not specific to NADPH oxidase-derived RONS, L-012 is also commonly used for screening NADPH oxidase inhibitors.
in vivo
L-012 sodium salt is well distributed in the mouse body and mediates a strong ROS/RNS-dependent luminescent signal in vivo and is useful for monitoring the development and regulation of inflammation in living organisms[2].
storage
Store at -20°C
sodium 8-amino-5-chloro-1-oxo-7-phenyl-2H-pyrido[3,4-d]pyridazin-4-olate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from sodium 8-amino-5-chloro-1-oxo-7-phenyl-2H-pyrido[3,4-d]pyridazin-4-olate manufacturers
- Product
- L 012 sodium salt 143556-24-5
- Price
- US $3.90-5.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-12