3-(HYDROXYMETHYL)BENZALDEHYDE
- Product Name
- 3-(HYDROXYMETHYL)BENZALDEHYDE
- CAS No.
- 52010-98-7
- Chemical Name
- 3-(HYDROXYMETHYL)BENZALDEHYDE
- Synonyms
- 130910;3-FORMYLBENZYL ALCOHOL;m-(Hydroxymethyl)benzaldehyde;3-(HYDROXYMETHYL)BENZALDEHYDE;Benzaldehyde, 3-(hydroxymethyl)-
- CBNumber
- CB2343640
- Molecular Formula
- C8H8O2
- Formula Weight
- 136.15
- MOL File
- 52010-98-7.mol
3-(HYDROXYMETHYL)BENZALDEHYDE Property
- Melting point:
- 120℃
- Boiling point:
- 282℃
- Density
- 1.184
- Flash point:
- 118℃
- storage temp.
- 2-8°C, stored under nitrogen
- pka
- 14.10±0.10(Predicted)
- form
- solid
- Appearance
- Colorless to off-white Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- PH017016
- Product name
- 3-(Hydroxymethyl)benzaldehyde
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $167
- Updated
- 2023/06/20
- Product number
- F697420
- Product name
- 3-FormylbenzylAlcohol
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 4151CU
- Product name
- 3-(Hydroxymethyl)benzaldehyde
- Packaging
- 1g
- Price
- $863
- Updated
- 2021/12/16
- Product number
- CM219864
- Product name
- 3-(Hydroxymethyl)benzaldehyde
- Purity
- 95%
- Packaging
- 1g
- Price
- $309
- Updated
- 2021/12/16
- Product number
- 52010987
- Product name
- 3-(Hydroxymethyl)benzaldehyde
- Packaging
- 1g
- Price
- $336.6
- Updated
- 2021/12/16
3-(HYDROXYMETHYL)BENZALDEHYDE Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of the American Chemical Society, 105, p. 7175, 1983 DOI: 10.1021/ja00362a028
Synthesis
626-19-7
52010-98-7
General procedure for the synthesis of 3-(hydroxymethyl)benzaldehyde from m-toluenedicarboxaldehyde: NaBH4 (1.7 g) was slowly added to a mixed solution of ethanol (100 mL) and tetrahydrofuran (150 mL) of m-toluenedicarboxaldehyde (1b, 20.0 g). The reaction mixture was stirred under ice bath conditions for 6 hours. Upon completion of the reaction, the pH was adjusted to 5-6 with 2 M hydrochloric acid solution to quench the reaction. Subsequently, the solvent was removed by rotary evaporator and the residue was extracted by adding water and ethyl acetate to the residue. The organic phase was washed with saturated NaCl solution and dried with anhydrous Na2SO4 for 8 hours. Finally, the product was purified by silica gel column chromatography using petroleum ether-ethyl acetate (5:1, v/v) as eluent to afford the target compound 3-(hydroxymethyl)benzaldehyde (2b, 16.4 g, 80.2% yield).
References
[1] Organic and Biomolecular Chemistry, 2016, vol. 14, # 45, p. 10688 - 10694
[2] Journal of Organometallic Chemistry, 2010, vol. 695, # 1, p. 82 - 89
[3] Dalton Transactions, 2015, vol. 44, # 9, p. 4054 - 4062
[4] Molecules, 2016, vol. 21, # 7,
[5] Patent: CN107522647, 2017, A. Location in patent: Paragraph 0082; 0083
3-(HYDROXYMETHYL)BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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