3-BOC-AMINO-2,6-DIOXOPIPERIDINE

Product Name: 3-BOC-AMINO-2,6-DIOXOPIPERIDINE
CAS No.: 31140-42-8
Chemical Name: 3-BOC-AMINO-2,6-DIOXOPIPERIDINE
Synonyms: (Lenalidomide Intermediate);Pomalidomide/lenalidomide INT I;3-BOC-AMINO-2,6-DIOXOPIPERIDINE;3-(Boc-amino)piperidine-2,6-dione;TERT-BUTYL 2,6-DIOXOPIPERIDIN-3-YLCARBAMATE;tert-butyl N-(2,6-dioxo-3-piperidyl)carbamate;tert-Butyl N-(2,6-dioxopiperidin-3-yl)carbamate;3-N-tert butoxycarbonylamino-2,6-dioxo piperidine;tert-Butyl 2,6-dioxopiperidin-3-ylcarbamate;2,6-Dioxo-3-piperidinecarbamic acid tert-butyl ester
CBNumber: CB2346065
Molecular Formula: C10H16N2O4
Formula Weight: 228.24
MOL File: 31140-42-8.mol

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3-BOC-AMINO-2,6-DIOXOPIPERIDINE Property

Melting point:: 193.7-194.4 °C
Boiling point:: 423.0±34.0 °C(Predicted)
Density: 1.20
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly, Heated), DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 10.78±0.20(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: OTV000814
Product name: tert-Butyl 2,6-dioxopiperidin-3-ylcarbamate
Packaging: 1g
Price: $216
Updated: 2025/07/31

TRC

Product number: B692395
Product name: tert-Butyl 2,6-dioxopiperidin-3-ylcarbamate
Packaging: 10g
Price: $1110
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0023395
Product name: 3-BOC-AMINO-2,6-DIOXOPIPERIDINE
Purity: 95.00%
Packaging: 1G
Price: $1188.5
Updated: 2021/12/16

ChemScene

Product number: CS-0036724
Product name: tert-ButylN-(2,6-dioxopiperidin-3-yl)carbamate
Packaging: 25g
Price: $1572
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB151965
Product name: 3-Boc-amino-2,6-dioxopiperidine
Packaging: 10g
Price: $1675
Updated: 2021/12/16

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3-BOC-AMINO-2,6-DIOXOPIPERIDINE Chemical Properties,Usage,Production

Uses

tert-Butyl (2,6-Dioxopiperidin-3-yl)carbamate is an intermediate in the synthesis of Thalidomide-d4 (T338852), a labelled Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.

Synthesis

13726-85-7

31140-42-8

General procedure for the synthesis of 3-Boc-amino-2,6-dioxopiperidine from BOC-L-glutamine: N-(tert-butoxycarbonyl)-L-glutamine (4.92 g, 20 mmol) and carbonyldiimidazole (1.70 g, 10.5 mmol) were dissolved in tetrahydrofuran (100 mL) and heated to reflux for 9 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was recrystallized from hot ethyl acetate to afford the target compound 3-Boc-amino-2,6-dioxopiperidine (2.04 g, 45% yield) as white crystals. Melting point: 214-215 °C; 1H NMR (DMSO-d6) δ 4.22 (dd, J = 6.2 Hz, J = 11.0 Hz, 1H), 2.77-2.65 (m, 1H), 2.45 (m, 1H), 1.96-1.87 (m, 2H), 1.40 (s, 9H); mass spectrum (CI/CH4) m/z 227 [M-1 ]+.

References

[1] Organic Letters, 2003, vol. 5, # 16, p. 2865 - 2867
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 21, p. 5819 - 5824
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 2, p. 650 - 662
[4] Patent: WO2005/28436, 2005, A2. Location in patent: Page/Page column 30; 53
[5] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 21, p. 5260 - 5262

3-BOC-AMINO-2,6-DIOXOPIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BOC-AMINO-2,6-DIOXOPIPERIDINE Suppliers

China 97 India 6 Sweden 1 Ukraine 1 United Kingdom 2 United States 13 Global 120

J & K SCIENTIFIC LTD.

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View Lastest Price from 3-BOC-AMINO-2,6-DIOXOPIPERIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-BOC-AMINO-2,6-DIOXOPIPERIDINE 31140-42-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-17

Career Henan Chemical Co

Product: 3-BOC-AMINO-2,6-DIOXOPIPERIDINE 31140-42-8
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

31140-42-8, 3-BOC-AMINO-2,6-DIOXOPIPERIDINERelated Search:

2-Amino-3-nitrobenzoic acid 3-Aminophthalimide 3-Nitrophthalimide 3-Nitrophthalic anhydride 3-(HYDROXYMETHYL)-BENZOIC ACID 3-AMINOPHTHALIC ACID HYDROCHLORIDE 3-IODOPHTHALIC ACID 1-Methyl-3-nitrophthalate 3-Oxocyclopentanecarboxylic acid 3-HYDROXYPHTHALIC ANHYDRIDE 4-Hydroxyphthalic acid 3-AMINOPHTHALIC ACID Luminol 3-BOC-AMINO-2,6-DIOXOPIPERIDINE

TERT-BUTYL 2,6-DIOXOPIPERIDIN-3-YLCARBAMATE

3-BOC-AMINO-2,6-DIOXOPIPERIDINE

CarbaMic acid, (2,6-dioxo-3-piperidinyl)-, 1,1-diMethylethyl ester

2,6-Dioxo-3-piperidinecarbamic acid tert-butyl ester

tert-Butyl N-(2,6-dioxopiperidin-3-yl)carbamate

1-amino-2,6-dioxo-3-piperidinecarboxylic acid tert-butyl ester

Pomalidomide/lenalidomide INT I

Carbamic acid, N-(2,6-dioxo-3-piperidinyl)-, 1,1-dimethylethyl ester

1,1-Dimethylethyl N-(2,6-dioxo-3-piperidinyl)carbamate

tert-butyl N-(2,6-dioxo-3-piperidyl)carbamate

tert-Butyl N-(2,6-dioxopiperidin-3-yl)carbamate (Pomalidomide Impurity)

3-(Boc-amino)piperidine-2,6-dione

3-N-tert butoxycarbonylamino-2,6-dioxo piperidine

<i>tert</i>-Butyl 2,6-dioxopiperidin-3-ylcarbamate

(Lenalidomide Intermediate)

31140-42-8

31140-52-8

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