4-(3-CHLOROPHENYL)-ALPHA-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL HYDROCHLORIDE

Product Name: 4-(3-CHLOROPHENYL)-ALPHA-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL HYDROCHLORIDE
CAS No.: 734517-40-9
Chemical Name: 4-(3-CHLOROPHENYL)-ALPHA-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL HYDROCHLORIDE
Synonyms: BRL 15572;BRL-15572 free;BRL 15572 (free base);1-Piperazineethanol, 4-(3-chlorophenyl)-α-(diphenylmethyl)-;3-(4-(3-Chlorophenyl)piperazin-1-yl)-1,1-diphenylpropan-2-ol;4-(3-Chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol hydrochloride;4-(3-CHLOROPHENYL)-ALPHA-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL HYDROCHLORIDE
CBNumber: CB2347239
Molecular Formula: C25H27ClN2O
Formula Weight: 406.95
MOL File: Mol file

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4-(3-CHLOROPHENYL)-ALPHA-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL HYDROCHLORIDE Property

storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: >40 mg/mL

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Safety

Hazard Codes: Xn
Risk Statements: 20/22-36/37/38
Safety Statements: 26-36-45
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0028145
Product name: BRL-15572
Purity: 95.00%
Packaging: 5MG
Price: $505.76
Updated: 2021/12/16

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4-(3-CHLOROPHENYL)-ALPHA-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

BRL-15572 is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses[1].

Definition

ChEBI: 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol is an N-alkylpiperazine that is 1-(3-chlorophenyl)piperazine carrying a 3,3-diphenyl-2-hydroxyprop-1-yl group at position 4. A selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types. It has a role as a serotonergic antagonist and a geroprotector. It is a N-alkylpiperazine, a N-arylpiperazine, a secondary alcohol and a member of monochlorobenzenes. It is a conjugate base of a 4-(3-chlorophenyl)-1-(2-hydroxy-3,3-diphenylpropyl)piperazin-1-ium(1+).

References

[1] Price GW, et, al. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep; 356(3): 312-20. DOI:10.1007/pl00005056
[2] Geovanna NQ, et, al. Antinociceptive effect of (-)-epicatechin in inflammatory and neuropathic pain in rats. Behav Pharmacol. 2018 Apr; 29(2 and 3-Spec Issue): 270-279. DOI:10.1097/FBP.0000000000000320
[3] Hagan JJ, et, al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23; 331(2-3): 169-74. DOI:10.1016/s0014-2999(97)01055-8

4-(3-CHLOROPHENYL)-ALPHA-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(3-CHLOROPHENYL)-ALPHA-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL HYDROCHLORIDE Suppliers

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734517-40-9, 4-(3-CHLOROPHENYL)-ALPHA-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL HYDROCHLORIDERelated Search:

4-(3-CHLOROPHENYL)-ALPHA-(DIPHENYLMETHYL)-1-PIPERAZINEETHANOL HYDROCHLORIDE

BRL 15572

4-(3-Chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol hydrochloride

1-Piperazineethanol, 4-(3-chlorophenyl)-α-(diphenylmethyl)-

BRL 15572 (free base)

BRL-15572 free

3-(4-(3-Chlorophenyl)piperazin-1-yl)-1,1-diphenylpropan-2-ol

734517-40-9

C25H27ClN2OHCl