ChemicalBook > CAS DataBase List > 5-methyl-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]pyrazine-2-carboxamide

5-methyl-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]pyrazine-2-carboxamide

Product Name
5-methyl-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]pyrazine-2-carboxamide
CAS No.
1189426-07-0
Chemical Name
5-methyl-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]pyrazine-2-carboxamide
Synonyms
D11-Glipizide;[2H11]-Glipizide;5-methyl-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]pyrazine-2-carboxamide;Glipizide d11Q: What is Glipizide d11 Q: What is the CAS Number of Glipizide d11 Q: What is the storage condition of Glipizide d11 Q: What are the applications of Glipizide d11
CBNumber
CB23595596
Molecular Formula
C21H16D11N5O4S
Formula Weight
456.602959558
MOL File
1189426-07-0.mol
More
Less

5-methyl-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]pyrazine-2-carboxamide Property

storage temp. 
Store at -20°C
solubility 
DMSO: slightly soluble,Ethyl Acetate: slightly soluble
form 
A solid
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
30074
Product name
Glipizide-d11
Packaging
500μg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
30074
Product name
Glipizide-d11
Packaging
1mg
Price
$290
Updated
2024/03/01
TRC
Product number
G410227
Product name
Glipizide-d11
Packaging
1mg
Price
$145
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0006543
Product name
GLIPIZIDE-D11
Purity
95.00%
Packaging
1MG
Price
$721.88
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0006543
Product name
GLIPIZIDE-D11
Purity
95.00%
Packaging
10MG
Price
$1732.5
Updated
2021/12/16
More
Less

5-methyl-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]pyrazine-2-carboxamide Chemical Properties,Usage,Production

Description

Glipizide-d11 is intended for use as an internal standard for the quantification of glipizide by GC- or LC-MS. Glipizide is a hypoglycemic agent. It inhibits ATP-sensitive potassium (KATP) channels in primary mouse pancreatic β cells (IC50 = 6.4 nM). Glipizide induces insulin release from isolated rat pancreatic tissue with an EC50 value of 40 nM. Dietary administration of glipizide (5 mg/kg per day for 10 days) increases the number of insulin receptors on isolated and purified mouse liver plasma membranes. It reduces plasma glucose and triglyceride, but not total cholesterol, levels and increases plasma insulin levels in a rat model of diabetes induced by a high-fat diet and streptozotocin (STZ; ) when administered orally at a dose of 5 mg/kg. Formulations containing glipizide have been used in the treatment of type 2 diabetes.

Uses

Labelled Glipizide (G410225). A sulfonylurea hypoglycemic agent. Used as an antidiabetic.

References

[1] B J ZüNKLER. Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1988, 337 2: 225-230. DOI: 10.1007/bf00169252
[2] A HERCHUELZ  W J M. Insulinotropic potency of glipizide in vitro.[J]. Diabetologia, 1973: 309-310. DOI: 10.1007/bf01218439
[3] MARK N. FEINGLOS  HAROLD E L. Sulphonylureas increase the number of insulin receptors[J]. Nature, 1978, 276 5684: 184-185. DOI: 10.1038/276184a0
[4] K. SRINIVASAN. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening[J]. Pharmacological research, 2005, 52 4: Pages 313-320. DOI: 10.1016/j.phrs.2005.05.004

5-methyl-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]pyrazine-2-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-methyl-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]pyrazine-2-carboxamide Suppliers

Canada 1 China 22 India 4 United States 1 Global 28
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Nanjing Haolv Biotechnology Co.,Ltd
Tel
025-84622273 17361806303
Email
kexin.zhou@haolvbiotech.com
Country
China
ProdList
3019
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
ChengDu SinoStandards Bio-Tech Co.,Ltd. ，
Tel
028-83243028 19136088901
Email
sinostandards@163.com
Country
China
ProdList
4976
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
29668
Advantage
58
Yancheng Tongming Biotechnology Co., Ltd.
Tel
15195160625
Email
2863565288@qq.com
Country
China
ProdList
5192
Advantage
58
LGC Science (Shanghai) Ltd.
Tel
17717235263
Email
cindy.yang@lgcgroup.com
Country
China
ProdList
18003
Advantage
58
Shanghai isotope chemical co.,ltd
Tel
021-51600108 13062666369
Email
sales@isotopechem.com
Country
China
ProdList
5000
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
17301488900
Fax
025-85560043
Email
judy.xia@synzest.com
Country
China
ProdList
12582
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
rose.shi@synzest.com
Country
China
ProdList
6210
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
29573
Advantage
58
Tanmo Quality Inspection Technology Co., Ltd.
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
6043
Advantage
58
BePure (Beijing) Biotechnology Co.
Tel
58896805
Email
7993601name@qq.com
Country
CHINA
ProdList
6620
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
ShangHai ZskBio CO., LTD
Tel
021-58056897 15399714481
Email
info@zsklab.com
Country
China
ProdList
7190
Advantage
58
Xingwang Biotechnology Co., Ltd. (Ruijing Testing Company, please do not buy)
Tel
15017521343
Country
CHINA
ProdList
186
Advantage
58
Shanghai Xiyuan Biotechnology Co., Ltd
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6934
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

1189426-07-0, 5-methyl-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]pyrazine-2-carboxamideRelated Search:


  • 5-methyl-N-[2-[4-[(1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]pyrazine-2-carboxamide
  • [2H11]-Glipizide
  • Glipizide d11Q: What is Glipizide d11 Q: What is the CAS Number of Glipizide d11 Q: What is the storage condition of Glipizide d11 Q: What are the applications of Glipizide d11
  • D11-Glipizide
  • 1189426-07-0
  • C21H16D11N5O4S