ChemicalBook > CAS DataBase List > 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE

3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE

Product Name: 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
CAS No.: 80288-49-9
Chemical Name: 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
Synonyms: Furafilina;FURAFYLLINE;Furafyllinum;Furatheophylline;Furafylline, PDE inhibitor;Furafylline, 10 mM in DMSO;FURAFYLLINE INHIBITOR OF CYTOCHRO;Cytochrome P450,inhibit,Inhibitor,CYPs,Furafylline;3-(Furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H,7H)-dione;3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
CBNumber: CB2360403
Molecular Formula: C12H12N4O3
Formula Weight: 260.25
MOL File: 80288-49-9.mol

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3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE Property

Melting point:: >162°C (dec.)
Boiling point:: 543.6±60.0 °C(Predicted)
Density: 1.443±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: ethanol: 0.33 mg/mL
form: solid
pka: 8.62±0.70(Predicted)
color: white
InChI: InChI=1S/C12H12N4O3/c1-7-13-9-10(14-7)16(6-8-4-3-5-19-8)12(18)15(2)11(9)17/h3-5H,6H2,1-2H3,(H,13,14)
InChIKey: KGQZGCIVHYLPBH-UHFFFAOYSA-N
SMILES: N1C2=C(N(CC3=CC=CO3)C(=O)N(C)C2=O)NC=1C

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F124
Product name: Furafylline
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $447
Updated: 2025/07/31

TCI Chemical

Product number: F1365
Product name: Furafylline
Packaging: 25MG
Price: $282
Updated: 2025/07/31

Cayman Chemical

Product number: 9000058
Product name: Furafylline
Purity: ≥95%
Packaging: 500μg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 9000058
Product name: Furafylline
Purity: ≥95%
Packaging: 1mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 9000058
Product name: Furafylline
Purity: ≥95%
Packaging: 5mg
Price: $317
Updated: 2024/03/01

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3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE Chemical Properties,Usage,Production

Uses

Furafylline is a selective inhibitor of human cytochrome P450. It is also reported to inhibit the oxidation of caffeine.

Definition

ChEBI: Furafylline is an oxopurine.

Biochem/physiol Actions

Furafylline (1,8-dimethyl-3-(2′ -furfuryl)methylxanthine) is a xanthine derivative. It is preferred in treating asthma. It serves as a N3-demethylation inhibitor of caffeine. Furafylline does not show much effect on human monooxygenase activities. It is considered as an efficient bronchodilator and as an inhibitor of anaphylactic reactions, when compared to theophylline.

in vivo

Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC₅₀ of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA^[1].

3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE manufacturers

Career Henan Chemical Co

Product: 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE 80288-49-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-30

80288-49-9, 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONERelated Search:

Diprophylline Furan Capecitabine Theophylline FURAN-2-YLMETHYL-UREA 1H-Imidazole-4-carboxamide,5-amino-2-methyl-(9CI) 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE 8-METHYLXANTHINE

FURAFYLLINE

3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE

Furafylline,3-(2-Furanylmethyl)-3,7-dihydro-1,8-dimethyl-1H-purine-2,6-dione

FURAFYLLINE INHIBITOR OF CYTOCHRO

1H-Purine-2,6-dione, 3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl-

3-(Furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H,7H)-dione

Cytochrome P450,inhibit,Inhibitor,CYPs,Furafylline

Furatheophylline

Furafilina

Furafyllinum

Furafylline, PDE inhibitor

Furafylline, 10 mM in DMSO

3-(furan-2-ylmethyl)-1,8-dimethyl-7H-purine-2,6-dione - [AC80897]

80288-49-9

C12H12N4O3

BioChemical

Cell Signaling and Neuroscience

Cell Biology

G Proteins and Cyclic Nucleotides

Cyclic Nucleotide Metabolism

Phosphodiesterase Inhibitors