CHLORIN E6

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Appearance Storage Solubility Shipping conditions

Product Name: CHLORIN E6
CAS No.: 19660-77-6
Chemical Name: CHLORIN E6
Synonyms: Chlorine e6;Photolon;CHLORIN E6 TRISODIUM SALT;orin E6;HLORIN E6;CHLORIN E6;Aids006251;Aids-006251;Chlorine a6;PHYTOCHLORIN
CBNumber: CB2365923
Molecular Formula: C34H36N4O6
Formula Weight: 596.67
MOL File: 19660-77-6.mol

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CHLORIN E6 Property

alpha: D20 -141° in acetone
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Isopropanol (Slightly, Heated, Sonicated)
form: Solid
Boiling point:: 1093.7±60.0 °C(Predicted)
Density: 1.306±0.06 g/cm3(Predicted)
color: Black
EPA Substance Registry System: 21H,23H-Porphine-7-propanoic acid, 3-carboxy-5-(carboxymethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-, (7S,8S)- (19660-77-6)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21684
Product name: Chlorin e6
Purity: ≥98%
Packaging: 50mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 21684
Product name: Chlorin e6
Purity: ≥98%
Packaging: 100mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 21684
Product name: Chlorin e6
Purity: ≥98%
Packaging: 250mg
Price: $208
Updated: 2024/03/01

Cayman Chemical

Product number: 21684
Product name: Chlorin e6
Purity: ≥98%
Packaging: 500mg
Price: $356
Updated: 2024/03/01

TRC

Product number: C380285
Product name: ChlorinE6
Packaging: 500mg
Price: $1190
Updated: 2021/12/16

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CHLORIN E6 Chemical Properties,Usage,Production

Appearance

Black solid powder with characteristic odor.

Storage

Store at frozen temperatures (-20 °C) in a dry an d dark location.

Solubility

Soluble in DMSO and Dimethylformamide, not soluble in neutral water, will dissolve in basic water (pH of 10 or greater).

Shipping conditions

Shipped with cold packs as non-hazardous chemical. This product is stable enough for a ordinary shipping and time spent in Customs.

Description

Chlorin E6 is a natural molecule and a promising photosensitizer. Chlorin E6 is isolated from renewable natural sources. Chlorin E6 is an attractive photodynamic therapy (PDT) drug candidate because of (1) its high absorption in the red spectral region, and (2) its low cost to make compared to other porphyrin-based PDT drugs. Chlorin E6 exhibits advantageous photophysical properties for PDT such as having long lifetimes in their photoexcited triplet states and high molar absorption in the red region of the visible spectrum. Moreover, a 664-nm laser light can penetrate tissue deeper that the 630-nm laser light used for other PDT drugs. Chlorin E6 is an important starting material for making PDT drug Talaporfin sodium (mono-L-aspartyl chlorin e6 or NPe6).
PDT is currently being used as an alternative therapeutic modality for a variety of malignant tumors. Studies have examined antitumor activity of Ce6-induced PDT (Ce6-PDT) both in vitro and in vivo using a rat tumor models. In one study three-week-old male Sprague-Dawley (SD) rats were inoculated s.c. on the right flank with 5x106 RK3E-ras cells. The animals were administered i.v. with Ce6 (10 mg/kg) and 24 h later, PDT was performed using a laser diode at a light dose of 100 J/cm2. Ce6-PDT generated reactive oxygen species and led to significant growth inhibition in RK3E-ras cell. In addition, Ce6-PDT induced apoptosis through the activation of caspase-3 and its downstream target, PARP cleavage. The protein level of anti-apoptotic bcl-2 was also reduced by Ce6-PDT in RK3E-ras cells. In in vivo experiments, application of Ce6- PDT led to a significant reduction of tumor size. PCNA immunostaining and TUNEL assay revealed that Ce6-PDT inhibited tumor cell proliferation and increased apoptosis. (source: Oncology Reports, 2009, 22(5). 1085-1091.)

Uses

Chlorin E6 is a photosensitizer.The conjugates of gold nanorods and chlorin e6 enhance the fluorescence detection and photodynamic therapy (PDT) of cancers.

Definition

ChEBI: Chlorin E6 is a member of chlorins.

CHLORIN E6 Preparation Products And Raw materials

Raw materials

Preparation Products

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CHLORIN E6 Suppliers

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View Lastest Price from CHLORIN E6 manufacturers

Career Henan Chemical Co

Product: CHLORIN E6 19660-77-6
Price: US $1.00/g
Min. Order: 100g
Purity: 98%min
Supply Ability: G/KG/T
Release date: 2019-12-23

19660-77-6, CHLORIN E6Related Search:

Co(II) meso-Tetra (4-methoxyphenyl) Porphine (1-3% chlorin) 5,10,15,20-tetra(m-hydroxyphenyl)chlorin Vanadyl meso-tetraphenylporphine chlorin free 5,10,15,20-TETRAPHENYL-21H,23H-PORPHINE ZINC, LOW CHLORIN, SYNTHETIC CHLORIN E6 Ni(II) meso-Tetraphenylporphine (chlorin free) COPPER-CHLORIN TPP MESO-TETRA(PENTAFLUOROPHENYL)PORPHINE CHLORIN FREE PORPHINE monoaspartyl chlorin e6 Chlorin e6 trisodium diaspartyl chlorin e6 21H,23H-Porphine-7-propanoic acid, 3-carboxy-13-ethenyl-18-ethyl-7,8-dihydro-2,5,8,12,17-pentamethyl-, (7S,8S)- CHLORIN E6 TRIMETHYL ESTER,3α,7,12,17-Tetramethyl-8-vinyl-13-ethyl-20-[(methoxycarbonyl)methyl]-18-(methoxycarbonyl)chlorin-2β-propionic acid methyl ester meso-Tetraphenylporphine (1-3% chlorin) Low-chlorin and high efficiency slushing agent Low-chlorin and low-alkali slushing agent

CHLORIN E6

PHYTOCHLORIN

Chlorophyll Impurity 11

12,17-tetramethyl-3-dihydro-(2s-trans)-thyl-7

21h,23h-porphine-2-propanoicacid,18-carboxy-20-(carboxymethyl)-8-ethenyl-13-e

(2S-trans)-18-carboxy-20-(carboxymethyl)-13-ethyl-2,3-dihydro-3,7,12,17-tetramethyl-8-vinyl-21H,23H-porphine-2-propionic acid

21H,23H-Porphine-7-propanoic acid, 3-carboxy-5-(carboxymethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-, (7S,8S)-

CHLORIN E6 TRISODIUM SALT

(2S-trans)-18-Crboxy-20-(carboxymethyl)-13-ethyl-2,3-dihydro-3,7,12,17-tetramethyl-8-vinyl-21H,23H-porphine-2-propionic acid

CHLORIN E6 Phytochlorin

3(S),7,12,17-Tetramethyl-13-ethyl-8-ethenyl-2,3-dihydro-18-carboxy-20-(carboxymethyl)-21H,23H-porphine-2(S)-propanoic acid

Aids006251

Aids-006251

Chlorine e6

Chlorine a6

Photochlorine

Photolon

Chlorin E6,>90%

(17S,18S)-18-(2-carboxyethyl)-20-(carboxymethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18,22,23-tetrahydroporphyrin-2-carboxylic acid

orin E6

(7S,8S)-7-(2-Carboxyethyl)-5-(carboxymethyl)-18-ethyl-2,8,12,17-tetramethyl-13-vinyl-7H,8H-porphyrin-3-carboxylic acid

(7S,8S)-3-Carboxy-5-(carboxymethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphine-7-propionic Acid

HLORIN E6

(2S-trans)-18-carboxy-20-(carboxymethyl)-13-ethyl-2,3-dihydro-3,7,12,17-tetramethyl-8-vinyl-21H,23H-porphine-2-propionic acid

19660-77-6

C34H36N4O6

Natural Porphyrins and Derivitives

Porphyrins