AFMK
- Product Name
- AFMK
- CAS No.
- 52450-38-1
- Chemical Name
- AFMK
- Synonyms
- AFMK;NSC 688263;AFMK, 10 mM in DMSO;Melatonin Impurtiy 5;Acetyl-N-formyl-5-methoxykynurenamine;Formyl-N-acetyl-5-methoxykynurenamine;N1-Acetyl-N2-forMyl-5-MethoxykynuraMine;N-acetyl-N-formyl-5-methoxykynurenamine;N--Acetyl-N-2-formyl-5-methoxykynurenamine;N-G-ACETYL-N-2-FORMYL-5-METHOXYKYNURENAMINE
- CBNumber
- CB2366733
- Molecular Formula
- C13H16N2O4
- Formula Weight
- 264.28
- MOL File
- 52450-38-1.mol
AFMK Property
- Melting point:
- 138-140°C
- Boiling point:
- 589.4±50.0 °C(Predicted)
- Density
- 1.216±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >10 mg/mL
- form
- solid
- pka
- 13.79±0.70(Predicted)
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SMB01335
- Product name
- <I>N</I><SUP>1</SUP>-Acetyl-<I>N</I><SUP>2</SUP>-formyl-5-methoxykynuramine
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $94
- Updated
- 2025/07/31
- Product number
- SMB01335
- Product name
- <I>N</I><SUP>1</SUP>-Acetyl-<I>N</I><SUP>2</SUP>-formyl-5-methoxykynuramine
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $376
- Updated
- 2025/07/31
- Product number
- 10005254
- Product name
- AFMK
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $23
- Updated
- 2024/03/01
- Product number
- 10005254
- Product name
- AFMK
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 10005254
- Product name
- AFMK
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $133
- Updated
- 2024/03/01
AFMK Chemical Properties,Usage,Production
Description
Melatonin is a neurotransmitter widely distributed in eukaryotes and is closely linked to circadean rhythms in mammals including humans. AFMK is a melatonin metabolite first identified in rat brain. AFMK has antioxidant and free radical scavenging activities in several experimental models. AFMK may also be measured in plasma as an index of melatonin synthesis and metabolism.
Chemical Properties
Light Brown Solid
Uses
A metabolite of melatonin (M215000).
Definition
ChEBI: N-gamma-Acetyl-N-2-Formyl-5-Methoxykynurenamine is an aromatic ketone.
in vivo
AFMK is a potent antioxidant in vivo. AFMK significantly reverses radiation-induced decline in the total antioxidant capacity of plasma in mice[2].
| Animal Model: | Male C57BL mice 8 wk of age[2] |
| Dosage: | 10 mg/kg body weight |
| Administration: | Intraperitoneal injection |
| Result: | Radiation-induced decline in the total antioxidant capacity of plasma was significantly reversed in AFMK pretreated mice. AFMK-pretreated irradiated groups showed a significantly lower value of comet tail length and % DNA in tail. |
IC 50
Human Endogenous Metabolite
References
[1] F. HIRATA. In vitro and in vivo formation of two new metabolites of melatonin.[J]. The Journal of Biological Chemistry, 1974, 3 1: 1311-1313. DOI: 10.1016/s0021-9258(19)42976-1
[2] DUN-XIAN TAN. N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant[J]. FASEB Journal, 2001, 15 12: 1-16. DOI: 10.1096/fj.01-0309fje
[3] CATHERINE HARTHé . Radioimmunoassay of N-acetyl-N-formyl-5-methoxykynuramine (AFMK): a melatonin oxidative metabolite[J]. Life sciences, 2003, 73 12: Pages 1587-1597. DOI: 10.1016/s0024-3205(03)00483-1
AFMK Preparation Products And Raw materials
Raw materials
Preparation Products
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