BUDIPINE

Product Name: BUDIPINE
CAS No.: 57982-78-2
Chemical Name: BUDIPINE
Synonyms: budipin;BUDIPINE;BUDIPINE USP/EP/BP;BUDIPINE(FORR&DONLY);4,4-diphenyl-1-tert-butyl-piperidine;1-TERT-BUTYL-4,4-DIPHENYL-PIPERIDINE;1-(1,1-dimethylethyl)-4,4-diphenylpiperidine;1-(1,1-dimethylethyl)-4,4-diphenyl-piperidin;Piperidine,1-(1,1-dimethylethyl)-4,4-diphenyl-;monoamine oxidase type B (MAO-B),inhibit,CNS disorders,Parkinson disease,Budipine,Inhibitor,dopaminergic
CBNumber: CB2369325
Molecular Formula: C21H27N
Formula Weight: 293.45
MOL File: 57982-78-2.mol

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BUDIPINE Property

Melting point:: 108.5°C
Boiling point:: 425.29°C (rough estimate)
Density: 0.9665 (rough estimate)
refractive index: 1.4900 (estimate)
storage temp.: 2-8°C
solubility: DMSO : 25 mg/mL (85.19 mM; Need ultrasonic)
pka: 10.36±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: B820055
Product name: 1-(tert-Butyl)-4,4-diphenylpiperidine
Packaging: 1mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB156517
Product name: 1-tert-butyl-4,4-Diphenyl-piperidine
Packaging: 5mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB156517
Product name: 1-tert-butyl-4,4-Diphenyl-piperidine
Packaging: 10mg
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: M128
Product name: Budipine
Packaging: 5mg
Price: $108
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB156517
Product name: 1-tert-butyl-4,4-Diphenyl-piperidine
Packaging: 25mg
Price: $150
Updated: 2021/12/16

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BUDIPINE Chemical Properties,Usage,Production

Description

Parkinsan was launched in Germany as a centrally-active anti-Parkinsonian agent. It can be prepared in three steps: a Mannich-aldol sequence to assemble the 4-phenylpiperidine scaffold followed by a Friedel-Crafts reaction to introduce the second phenyl ring. Parkinsan is effective for the treatment of Parkinsonian tremors and is similar in action to, but more potent than, biperiden. It exhibits use-dependent, open channel, uncompetitive NMDA receptor antagonistic activity. This may occur by binding to the PCP site in addition to interacting with sigma, binding sites in the frontal cortex. Parkinsan is also an antagonist at presynaptic muscarinic autoreceptors but facilitation of direct or indirect dopaminergic transmission does not contribute to its actions. While its mechanism of action is not completely understood, it has a weak inhibitory effect on dopamine reuptake, inhibits evoked GABA release (with low affinity for GABA-A receptors and a lower affinity for benzodiazepine receptors), and has a weak inhibitory effect on MAO-B.

Originator

Byk Gulden (Germany)

Definition

ChEBI: Budipine is a diarylmethane.

Manufacturing Process

24.4 g of 1-(t-butyl)-4-hydroxy-4-phenylpiperidine are suspended in 150 ml of anhydrous benzene. 61.5 g of finely pulverized anhydrous aluminum chloride are added in portions thereto within 25 min while stirring. The reaction temperature increases on starting addition of aluminum chloride to about 45°C. After about 20 min the temperature is increased to and maintained at about 50° to 55°C for about 1 hour. The resulting reaction solution is cooled to about 20°C and is poured into a mixture of ice and concentrated hydrochloric acid. After warming the mixture to room temperature, the hydrochloric acid layer together with the dark oil formed on decomposition is separated from the benzene layer and is washed with benzene. Water is added to said hydrochloric acid -oil phase, while stirring, in portions and in an amount sufficient to produce an almost clear solution. Said acid solution is rendered alkaline by the addition of 40% sodium hydroxide solution whereby the mixture is well cooled. The alkalized mixture is repeatedly extracted with ether. The combined ether extracts are dried over anhydrous potassium carbonate and are concentrated by evaporation of the ether. 24 g of the crude base are obtained as residue in the form of yellowish oil. A water clear oil boiling at 129-131°C/0.005 mm Hg is recovered by distillation of said crude oil in a high vacuum. The oil solidifies to crystals on standing for a short period of time. After recrystallization from aqueous dimethylformamide, the resulting 1-methyl-4,4-diphenylpiperidine has a melting point of 72-74°C.
Its hydrochloride is produced by dissolving the base in acetic acid ethyl ester and adding an ethereal hydrochloric acid solution thereto. After recrystallization from acetic acid ethyl ester, the melting point of the hydrochloride is 152-154°C.

brand name

Parkinsan

Therapeutic Function

Antiparkinsonian, Antidepressant

BUDIPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BUDIPINE Suppliers

China 33 Europe 2 Germany 2 India 1 United Kingdom 5 United States 9 Global 52

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

Shanghai AQBioPharma Co., Ltd.

Tel: 13764862135
Fax: 51370935-8011
Email: yaoliang.ni@aqbiopharma.com.cn
Country: China
ProdList: 2715
Advantage: 58

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4992
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9254
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15952
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20569
Advantage: 58

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View Lastest Price from BUDIPINE manufacturers

Dideu Industries Group Limited

Product: BUDIPINE 57982-78-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-26

Career Henan Chemical Co

Product: BUDIPINE 57982-78-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

57982-78-2, BUDIPINERelated Search:

1,3,5-Tri-tert-butylbenzene Diantimony trioxide Prodipine BUDIPINE 4-N-Methylbenzyl-N-carbethoxypiperidine dihydrochloride

BUDIPINE

1-(1,1-dimethylethyl)-4,4-diphenyl-piperidin

1-(1,1-dimethylethyl)-4,4-diphenylpiperidine

budipin

Piperidine,1-(1,1-dimethylethyl)-4,4-diphenyl-

1-TERT-BUTYL-4,4-DIPHENYL-PIPERIDINE

BUDIPINE(FORR&DONLY)

4,4-diphenyl-1-tert-butyl-piperidine

BUDIPINE USP/EP/BP

monoamine oxidase type B (MAO-B),inhibit,CNS disorders,Parkinson disease,Budipine,Inhibitor,dopaminergic

57982-78-2