ChemicalBook > CAS DataBase List > 5-Nitro-6-methyluracil
5-Nitro-6-methyluracil
- Product Name
- 5-Nitro-6-methyluracil
- CAS No.
- 16632-21-6
- Chemical Name
- 5-Nitro-6-methyluracil
- Synonyms
- NSC 40201;6-Methyl-5-Nit;-5-nitropyrimidine;6-metyl-5-nitrouracil;6-methyl-5-nitrouracil;5-NITRO-6-METHYLURACIL;2,4-Dihydroxy-6-methyL;6-Methyl-5-nitrouracil >5-Nitro-6-methyluracil ,98%;2,4-Dihydroxy-6-methyl-5-Nitro
- CBNumber
- CB2373609
- Molecular Formula
- C5H5N3O4
- Formula Weight
- 171.11
- MOL File
- 16632-21-6.mol
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5-Nitro-6-methyluracil Property
- Melting point:
- 290-291°C dec.
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMF, DMSO, Hot Methanol, Hot Water
- pka
- 6.24±0.10(Predicted)
- form
- Solid
- color
- Light Yellow Crystalline
- Water Solubility
- Soluble in DMF, DMSO, hot methanol and hot water.
- InChI
- InChI=1S/C5H5N3O4/c1-2-3(8(11)12)4(9)7-5(10)6-2/h1H3,(H2,6,7,9,10)
- InChIKey
- LIVYMRJSNFHYEN-UHFFFAOYSA-N
- SMILES
- C1(=O)NC(C)=C([N+]([O-])=O)C(=O)N1
- CAS DataBase Reference
- 16632-21-6(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41-40
- Safety Statements
- 26-39-36-22
- WGK Germany
- 3
- HS Code
- 29335990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- M2506
- Product name
- 6-Methyl-5-nitrouracil
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M2506
- Product name
- 6-Methyl-5-nitrouracil
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $33
- Updated
- 2025/07/31
Usbiological
- Product number
- 234348
- Product name
- 5-Nitro-6-methyluracil
- Packaging
- 5g
- Price
- $170
- Updated
- 2021/12/16
Usbiological
- Product number
- D3579-46
- Product name
- 2,4-Dihydroxy-6-methyl-5-nitropyrimidine
- Packaging
- 5g
- Price
- $375
- Updated
- 2021/12/16
TRC
- Product number
- D453250
- Product name
- 2,4-Dihydroxy-6-methyl-5-nitropyrimidine
- Packaging
- 50g
- Price
- $855
- Updated
- 2021/12/16
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5-Nitro-6-methyluracil Chemical Properties,Usage,Production
Chemical Properties
Light Yellow Crystalline Solid
Uses
A synthetic intermediate
Uses
5-Nitro-6-methyluracil, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
Synthesis
626-48-2
16632-21-6
The general procedure for the synthesis of 2,4-dihydroxy-6-methyl-5-nitropyrimidine from 6-methyluracil was as follows: the procedure was adapted from the Journal of Medicinal Chemistry. 6-Methylpyrimidine-2,4(1H,3H)-dione (7.0 g, 55.56 mmol) was slowly added to ice-cooled but concentrated sulfuric acid (26 mL), and the rate of addition was controlled to keep the internal temperature of the reaction system from exceeding 40 °C. Subsequently, fuming nitric acid (5.2 mL) was slowly added dropwise to the reaction mixture at a temperature below 15 °C. After completion of the dropwise addition, the cooling bath was removed and the reaction mixture was stirred at room temperature for 30 min. The reaction solution was carefully poured into 100 mL of crushed ice and stirred for 10 minutes before collecting the solid product that precipitated. The solid was washed with cold water and then dried under vacuum in the presence of phosphorus pentoxide. A yellow-green solid of 6-methyl-5-nitropyrimidine-2,4(1H,3H)-dione (7.92 g, 83% yield) was finally obtained.
References
[1] Journal of Chemical Research, Miniprint, 1989, # 9, p. 2086 - 2097
[2] Patent: WO2009/62258, 2009, A1. Location in patent: Page/Page column 97-98
[3] Synthetic Communications, 2007, vol. 37, # 14, p. 2421 - 2431
[4] ChemMedChem, 2018, vol. 13, # 2, p. 178 - 185
[5] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0030
5-Nitro-6-methyluracil Preparation Products And Raw materials
Raw materials
6-Methyluracil
Ethyl acetoacetate
Ethanol
Diethyl ether
Hydrochloric acid
Nitric acid
Phosphorus pentoxide
Sulfuric acid
UREA HYDROCHLORIDE
Potassium nitrate
Preparation Products
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View Lastest Price from 5-Nitro-6-methyluracil manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- 5-Nitro-6-methyluracil 16632-21-6
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-20
Honest Joy Holdings Limited
- Product
- 2,4-Dihydroxy-6-methyl-5-nitropyrimidine 16632-21-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.7%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08
Dideu Industries Group Limited
- Product
- 5-Nitro-6-methyluracil 16632-21-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-14
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