(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE
- Product Name
- (S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE
- CAS No.
- 451462-58-1
- Chemical Name
- (S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE
- Synonyms
- H1152;H1152P;H-1152;H 1152;H1152;(S)-H-1152 dihydrochloride;(S)-H-1152 (hydrochloride);(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE;4-methyl-5-[(2-methyl-1,4-diazepan-1-yl)sulfonyl]isoquinoline,dihydrochloride;Isoquinoline, 5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methyl-;(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepinedihydrochloride
- CBNumber
- CB2377081
- Molecular Formula
- C16H21N3O2S
- Formula Weight
- 319.42
- MOL File
- 451462-58-1.mol
(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE Property
- Boiling point:
- 519.6±60.0 °C(Predicted)
- Density
- 1.218±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- solubility
- 25℃: DMSO
- form
- Powder
- pka
- 9.76±0.40(Predicted)
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 10007653
- Product name
- (S)-H-1152 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 10007653
- Product name
- (S)-H-1152 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $66
- Updated
- 2024/03/01
- Product number
- 10007653
- Product name
- (S)-H-1152 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $274
- Updated
- 2024/03/01
- Product number
- 10007653
- Product name
- (S)-H-1152 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- 3714AH
- Product name
- (S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline
- Packaging
- 5mg
- Price
- $402
- Updated
- 2021/12/16
(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE Chemical Properties,Usage,Production
Description
Rho-associated kinase (ROCK), activated by GTP-
Definition
ChEBI: (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane is a member of the class of isoquinolines that is the sulfonamide formed by the formal condensation of the sulfo group of 4-methylisoquinoline-5-sulfonic acid with the 1-amino group of (S)-2-methyl-1,4-diazepane. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a member of isoquinolines and a N-sulfonyldiazepane. It is a conjugate base of a (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane(2+).
Biological Activity
Rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC 50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μ M for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea pig aorta (IC 50 = 190 nM) and displays proerectile effects in rats.
(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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