ChemicalBook > CAS DataBase List > C188-9

C188-9

Product Name: C188-9
CAS No.: 432001-19-9
Chemical Name: C188-9
Synonyms: TTI-101;C188-9;F0808-0084;C188-9, 10 mM in DMSO;STAT3 inhibitor TTI-101;STAT3 Inhibitor XIII, C188-9;C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084;C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084;N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide;N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide
CBNumber: CB23959200
Molecular Formula: C27H21NO5S
Formula Weight: 471.52
MOL File: 432001-19-9.mol

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C188-9 Property

Boiling point:: 680.9±65.0 °C(Predicted)
Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
form: A crystalline solid
pka: 8.14±0.50(Predicted)
color: Off-white to pink

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 573128
Product name: STAT3 Inhibitor XIII, C188-9
Purity: The Stat3 Inhibitor XIII, C188-9 controls the biological activity of Stat3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Packaging: 10 mg
Price: $177
Updated: 2025/07/31

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 25mg
Price: $290
Updated: 2021/12/16

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 10mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 50mg
Price: $460
Updated: 2021/12/16

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C188-9 Chemical Properties,Usage,Production

Uses

C188-9 (TTI-101) is a STAT3 inhibitor, with a Kd of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts[1][2][3][4].

Biological Activity

C188-9 (TTI 101) is a potent STAT3 inhibitor, binds STAT3 with high affinity, Kd=4.7±0.4 nM. It is well tolerated in mice, has good oral bioavailability, and is mainly enriched in tumor tissues.

in vitro

C188-9 is a small molecule inhibitor of STAT3, targeting the phosphotyrosine peptide binding site in the SH2 region of STAT3 with a Ki value of 136 nM. It does not inhibit upstream Jak or Src kinases.

in vivo

C188-9 inhibited tumor growth in mice bearing UM-SCC-17B xenografts after administration of C188-9. C188-9 was well tolerated in mice, had good oral bioavailability, and was concentrated in tumor tissue after administration.

target

Target	Value
STAT3 (Cell-free)	4.7 nM(Kd)

IC 50

STAT3: 4.7 nM (Kd)

References

[1] Silva KA, et al. Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem. 2015 Apr 24;290(17):11177-87. DOI:10.1074/jbc.M115.641514
[2] Redell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011 May 26;117(21):5701-9. DOI:10.1182/blood-2010-04-280123
[3] Bharadwaj U, et al. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 3;7(18):26307-30. DOI:10.18632/oncotarget.8368
[4] Redell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011;117(21):5701-5709. DOI:10.1182/blood-2010-04-280123

C188-9 Preparation Products And Raw materials

Raw materials

Preparation Products

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432001-19-9, C188-9Related Search:

C188-9

C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084

N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide

C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084

F0808-0084

TTI-101

Benzenesulfonamide, N-(1',2-dihydroxy[1,2'-binaphthalen]-4'-yl)-4-methoxy-

N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide

C1889,Apoptosis,STAT,Inhibitor,C188 9,C-188-9,C188-9,TTI101,TTI 101,inhibit

STAT3 inhibitor TTI-101

C188-9, 10 mM in DMSO

STAT3 Inhibitor XIII, C188-9

432001-19-9