C188-9

ChemicalBook > CAS DataBase List > C188-9

Product Name: C188-9
CAS No.: 432001-19-9
Chemical Name: C188-9
Synonyms: TTI-101;C188-9;F0808-0084;STAT3 inhibitor TTI-101;C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084;C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084;N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide;N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide;N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide;Benzenesulfonamide, N-(1',2-dihydroxy[1,2'-binaphthalen]-4'-yl)-4-methoxy-
CBNumber: CB23959200
Molecular Formula: C27H21NO5S
Formula Weight: 471.52
MOL File: 432001-19-9.mol

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C188-9 Property

Boiling point:: 680.9±65.0 °C(Predicted)
Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
form: A crystalline solid
pka: 8.14±0.50(Predicted)
color: Off-white to pink

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 10mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 25mg
Price: $290
Updated: 2021/12/16

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 50mg
Price: $460
Updated: 2021/12/16

ChemScene

Product number: CS-0044737
Product name: C188-9
Purity: 99.50%
Packaging: 100mg
Price: $720
Updated: 2021/12/16

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C188-9 Chemical Properties,Usage,Production

Biological Activity

C188-9 (TTI 101) is a potent STAT3 inhibitor, binds STAT3 with high affinity, Kd=4.7±0.4 nM. It is well tolerated in mice, has good oral bioavailability, and is mainly enriched in tumor tissues.

in vitro

C188-9 is a small molecule inhibitor of STAT3, targeting the phosphotyrosine peptide binding site in the SH2 region of STAT3 with a Ki value of 136 nM. It does not inhibit upstream Jak or Src kinases.

in vivo

C188-9 inhibited tumor growth in mice bearing UM-SCC-17B xenografts after administration of C188-9. C188-9 was well tolerated in mice, had good oral bioavailability, and was concentrated in tumor tissue after administration.

target

Target	Value
STAT3 (Cell-free)	4.7 nM(Kd)

C188-9 Preparation Products And Raw materials

Raw materials

Preparation Products

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432001-19-9, C188-9Related Search:

C188-9

C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084

N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide

C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084

F0808-0084

TTI-101

Benzenesulfonamide, N-(1',2-dihydroxy[1,2'-binaphthalen]-4'-yl)-4-methoxy-

N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide

C1889,Apoptosis,STAT,Inhibitor,C188 9,C-188-9,C188-9,TTI101,TTI 101,inhibit

STAT3 inhibitor TTI-101

N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide

432001-19-9